{"product_id":"abcam-ab142073","title":"Abcam, ab142073, AGK2, sirtuin2 (SIRT2) inhibitor","description":"\u003cp\u003eSize: 10mg\u003cbr\u003e\nMW 434.3 Da, Purity \u0026gt;95%. Selective reversible cell-permeable sirtuin2 (SIRT2) inhibitor (IC 50  = 3.5 μM). Protects dopamine neurons from α-synuclein toxicity  in vivo . Orally active.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:304896-28-4,\u003cbr\u003e\nPurity:\u0026gt;95%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:434.3 Da,\u003cbr\u003e\nMolecular formula:C23H13Cl2N3O2,\u003cbr\u003e\nPubChem:2130404,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 10 mM,\u003cbr\u003e\nBiochemical name:2-Propenamide, 2-cyano-3-(5-(2,5-dichlorophenyl)-2-furanyl)-N-5-quinolinyl-,\u003cbr\u003e\nBiological description:Selective reversible cell-permeable sirtuin2 (SIRT2) inhibitor (IC50 = 3.5 μM). Protects dopamine neurons from α-synuclein toxicity in vivo. Orally active.,\u003cbr\u003e\nCanonical smiles:C1=CC2=C(C=CC=N2)C(=C1)NC(=O)C(=CC3=CC=C(O3)C4=C(C=CC(=C4)Cl)Cl)C#N,\u003cbr\u003e\nIsomeric smiles:C1=CC2=C(C=CC=N2)C(=C1)NC(=O)\/C(=C\/C3=CC=C(O3)C4=C(C=CC(=C4)Cl)Cl)\/C#N,\u003cbr\u003e\nInChi:InChI=1S\/C23H13Cl2N3O2\/c24-15-6-8-19(25)18(12-15)22-9-7-16(30-22)11-14(13-26)23(29)28-21-5-1-4-20-17(21)3-2-10-27-20\/h1-12H,(H,28,29)\/b14-11+,\u003cbr\u003e\nInChiKey:SVENPFFEMUOOGK-SDNWHVSQSA-N,\u003cbr\u003e\nIUPAC Name:(E)-2-cyano-3-[5-(2,5-dichlorophenyl)furan-2-yl]-N-quinolin-5-ylprop-2-enamide\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called 1651 SIRT2 Inhibitor, AGK2. 1651-10 is the same size as the 10 mg size of ab142073.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSIRT2 also known as Sirtuin 2 is a member of the sirtuin family of proteins which are NAD+-dependent deacetylases known for regulating various cellular processes. SIRT2 has a molecular mass of approximately 43 kDa. Its expression is prominent in the cytoplasm but can also be found in the nucleus of cells particularly in the brain and liver tissues. The protein deacetylates various substrates influencing cellular processes including aging metabolism and neurodegeneration.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSIRT2 contributes to the regulation of cellular homeostasis and stress responses. This protein acts as a deacetylase modulating the acetylation status of key proteins and participates in various signaling pathways. It functions as part of a larger protein complex and interacts with substrates that include tubulin and histones. These interactions help SIRT2 control processes such as cell cycle differentiation and proliferation indicating its importance in maintaining normal cellular function.\u003cbr\u003e\nPathways\u003cbr\u003e\nSIRT2 plays an essential role in the insulin signaling pathway and the FoxO transcription factor pathway. In these pathways SIRT2 interacts with other sirtuins like SIRT1 which helps regulate metabolic homeostasis and oxidative stress responses. SIRT2's activity in deacetylating proteins such as p53 impacts cellular responses to DNA damage and genomic stability further integrating it into critical regulatory networks within the cell.\u003cbr\u003e\nSIRT2 relates to neurodegenerative diseases like Parkinson's disease and metabolic disorders such as obesity. Its involvement in deacetylating alpha-synuclein links SIRT2 to Parkinson's disease pathogenesis. In metabolic disorders abnormalities in SIRT2 activity can affect glucose and lipid metabolism connecting it with proteins like acetyl-CoA carboxylase. Understanding SIRT2's function offers potential therapeutic targets for these conditions and highlights its importance in disease regulation.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847448252585,"sku":"ab142073","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab142073","provider":"Iright","version":"1.0","type":"link"}