{"product_id":"abcam-ab142092","title":"Abcam, ab142092, A 83-01, ALK4, 5 and 7 kinase inhibitor","description":"\u003cp\u003eSize: 1mg\u003cbr\u003e\nMW 421.5 Da, Purity \u0026gt;98%. Potent, selective TGF-β type I receptor ALK5, type I activin\/nodal receptor ALK4 and type I nodal receptor ALK7 kinase inhibitor (IC 50  values are 12, 45 and 7.5 nM for ALK5, ALK4 and ALK7 respectively). TGF-β1 inhibitor. Inhibits TGF-β1-dependent α-SMA and collagen type I induction. Active  in vivo  and  in vitro .\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:909910-43-6,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:421.5 Da,\u003cbr\u003e\nMolecular formula:C25H19N5S,\u003cbr\u003e\nPubChem:16218924,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nBiochemical name:3-(6-methylpyridin-2-yl)-N-phenyl-4-(quinolin-4-yl)-1H-pyrazole-1-carbothioamide,\u003cbr\u003e\nBiological description:Potent, selective TGF-β type I receptor ALK5, type I activin\/nodal receptor ALK4 and type I nodal receptor ALK7 kinase inhibitor (IC50 values are 12, 45 and 7.5 nM for ALK5, ALK4 and ALK7 respectively). TGF-β1 inhibitor. Inhibits TGF-β1-dependent α-SMA and collagen type I induction. Active in vivo and in vitro.,\u003cbr\u003e\nCanonical smiles:CC1=NC(=CC=C1)C2=NN(C=C2C3=CC=NC4=CC=CC=C34)C(=S)NC5=CC=CC=C5,\u003cbr\u003e\nInChi:InChI=1S\/C25H19N5S\/c1-17-8-7-13-23(27-17)24-21(19-14-15-26-22-12-6-5-11-20(19)22)16-30(29-24)25(31)28-18-9-3-2-4-10-18\/h2-16H,1H3,(H,28,31),\u003cbr\u003e\nInChiKey:HIJMSZGHKQPPJS-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:3-(6-methylpyridin-2-yl)-N-phenyl-4-quinolin-4-ylpyrazole-1-carbothioamide,\u003cbr\u003e\nReconstitution:Reconstitute in DMSO\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called 1725 A 83-01. 1725-1 is the same size as the 1 mg size of ab142092.\u003cbr\u003e\nHandling\u003cbr\u003e\nWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.\u003cbr\u003e\nRefer to SDS for further information.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847491408041,"sku":"ab142092","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab142092","provider":"Iright","version":"1.0","type":"link"}