{"product_id":"abcam-ab142129","title":"Abcam, ab142129, (R,S)-Lenalidomide, Thalidomide analog, TNF alpha inhibitor","description":"\u003cp\u003eSize: 25mg \/ 100mg\u003cbr\u003e\nMW 259.26 Da, Purity \u0026gt;98%. Thalidomide (ab120032) analog and TNF-α inhibitor. Potent antitumor and anti-inflammatory effects. Modulates and potentiates host immune responses against multiple myeloma. Active in vitro.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:191732-72-6,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:259.26 Da,\u003cbr\u003e\nMolecular formula:C13H13N3O3,\u003cbr\u003e\nPubChem:216326,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 100 mM,\u003cbr\u003e\nBiochemical name:Lenalidomide,\u003cbr\u003e\nBiological description:Thalidomide (ab120032) analog and TNF-α inhibitor. Potent antitumor and anti-inflammatory effects. Modulates and potentiates host immune responses against multiple myeloma. Active in vitro.,\u003cbr\u003e\nCanonical smiles:C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3N,\u003cbr\u003e\nInChi:InChI=1S\/C13H13N3O3\/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18\/h1-3,10H,4-6,14H2,(H,15,17,18),\u003cbr\u003e\nInChiKey:GOTYRUGSSMKFNF-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called 1862 (R,S)-Lenalidomide. 1862-100 is the same size as the 100 mg size of ab142129.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nIkaros also known as IKZF1 is a zinc finger transcription factor with a mass of around 58 kDa. It is important for the development and function of the immune system specifically impacting lymphocyte differentiation. Ikaros is prominently expressed in hematopoietic cells including both B and T lymphocytes. IKZF3 another member of the Ikaros family serves similar roles while cereblon (CRBN) is part of the E3 ubiquitin ligase complex. CRBN is not a transcription factor but functions in protein ubiquitination and is expressed in multiple tissues suggesting diverse functions across different biological contexts.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nIkaros and IKZF3 act as transcriptional regulators shaping lymphocyte gene expression in the immune system. They form complexes with other proteins to exert their regulatory effects on chromatin and transcription. CRBN as a substrate receptor for the CUL4-RBX1-DDB1-CRBN E3 ubiquitin ligase complex influences protein degradation pathways. It does not directly regulate transcription but plays a part in controlling protein turnover which can have regulatory impacts on cell signaling pathways.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe significance of Ikaros and IKZF3 extends to the JAK-STAT signaling and B-cell receptor signaling pathways. In these pathways their transcriptional regulation affects gene expression critical for immune cell function. CRBN's role through ubiquitination connects indirectly to these pathways by modulating protein stability. Together they interact within complex networks of protein regulation influencing cellular responses to external stimuli.\u003cbr\u003e\nIkaros and IKZF3 are linked to hematologic malignancies such as leukemia. These transcription factors' mutations or dysregulation can lead to uncontrolled cell proliferation. The connection of CRBN to diseases like multiple myeloma comes from its interaction with the drug lenalidomide a derivative of thalidomide which modulates the immune response by degrading IKZF proteins. These interactions highlight the therapeutic targeting potential of CRBN in relation to drug efficacy and disease modulation.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847449661609,"sku":"ab142129","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab142129","provider":"Iright","version":"1.0","type":"link"}