{"product_id":"abcam-ab142218","title":"Abcam, ab142218, TAPI-1, TNF alpha processing inhibitor","description":"\u003cp\u003eSize: 1mg\u003cbr\u003e\nMW 499.6 Da, Purity \u0026gt;95%. Stable, selective inhibitor of TNF-α processing (IC 50  = ~100 nM). Inhibits TACE (P\u0026lt; 0.01) and other metalloproteases  in vivo . Blocks release of TNF-α (IC 50  = 50-100 μM), APP (IC 50  = 1-8 μM), ACE (IC 50  = 10 μM), IL6R (IC 50  = 5-10 μM), TNFRI (IC 50  = 5-10 μM), TNFRII (IC 50  = 25-50 μM), and ObRa (leptin receptor), but not CSF-1  in vivo . Structural analog of TAPI-0.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:171235-71-5,\u003cbr\u003e\nPurity:\u0026gt;95%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:499.6 Da,\u003cbr\u003e\nMolecular formula:C26H37N5O5,\u003cbr\u003e\nPubChem:9827273,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 10 mM,\u003cbr\u003e\nBiochemical name:TNF-alpha Protease Inhibitor-1,\u003cbr\u003e\nBiological description:Stable, selective inhibitor of TNF-α processing (IC50 = ~100 nM). Inhibits TACE (P\u0026lt; 0.01) and other metalloproteases in vivo. Blocks release of TNF-α (IC50 = 50-100 μM), APP (IC50 = 1-8 μM), ACE (IC50 = 10 μM), IL6R (IC50 = 5-10 μM), TNFRI (IC50 = 5-10 μM), TNFRII (IC50 = 25-50 μM), and ObRa (leptin receptor), but not CSF-1 in vivo. Structural analog of TAPI-0.,\u003cbr\u003e\nCanonical smiles:CC(C)CC(CC(=O)NO)C(=O)NC(CC1=CC2=CC=CC=C2C=C1)C(=O)NC(C)C(=O)NCCN,\u003cbr\u003e\nIsomeric smiles:C[C@@H](C(=O)NCCN)NC(=O)[C@H](CC1=CC2=CC=CC=C2C=C1)NC(=O)C(CC(C)C)CC(=O)NO,\u003cbr\u003e\nInChi:InChI=1S\/C26H37N5O5\/c1-16(2)12-21(15-23(32)31-36)25(34)30-22(26(35)29-17(3)24(33)28-11-10-27)14-18-8-9-19-6-4-5-7-20(19)13-18\/h4-9,13,16-17,21-22,36H,10-12,14-15,27H2,1-3H3,(H,28,33)(H,29,35)(H,30,34)(H,31,32)\/t17-,21?,22-\/m0\/s1,\u003cbr\u003e\nInChiKey:AWNBSWDIOCXWJW-OWHMDLSXSA-N,\u003cbr\u003e\nIUPAC Name:N-[(2S)-1-[[(2S)-1-(2-aminoethylamino)-1-oxopropan-2-yl]amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-N'-hydroxy-2-(2-methylpropyl)butanediamide\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called 2068 TAPI-1. 2068-1 is the same size as the 1 mg size of ab142218.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847420825769,"sku":"ab142218","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab142218","provider":"Iright","version":"1.0","type":"link"}