{"product_id":"abcam-ab142262","title":"Abcam, ab142262, Bryostatin 1, protein kinase C activator","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nMW 905 Da, Purity \u0026gt;98%. Potent protein kinase C activator with high binding affinity (K i  = 1.35 nM). A macrolide lactone. Potently downregulates PKCα, PKCδ and PKCε compared to PMA (ab120297) .  Range of biological activities. Active  in vivo .\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:83314-01-6,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nSource:Bugula neritina,\u003cbr\u003e\nMolecular weight:905 Da,\u003cbr\u003e\nMolecular formula:C47H68O17,\u003cbr\u003e\nPubChem:5280757,\u003cbr\u003e\nNature:Native,\u003cbr\u003e\nSolubility:Soluble in DMSO to 25 mMSoluble in ethanol to 25 mM,\u003cbr\u003e\nBiochemical name:Bryostatin 1,\u003cbr\u003e\nBiological description:Potent protein kinase C activator with high binding affinity (Ki = 1.35 nM). A macrolide lactone. Potently downregulates PKCα, PKCδ and PKCε compared to PMA (ab120297). Range of biological activities. Active in vivo.,\u003cbr\u003e\nCanonical smiles:CCCC=CC=CC(=O)OC1C(=CC(=O)OC)CC2CC(OC(=O)CC(CC3CC(C(C(O3)(CC4CC(=CC(=O)OC)CC(O4)C=CC(C1(O2)O)(C)C)O)(C)C)OC(=O)C)O)C(C)O,\u003cbr\u003e\nIsomeric smiles:CCC\/C=C\/C=C\/C(=O)O[C@H]1\/C(=C\/C(=O)OC)\/C[C@H]2C[C@@H](OC(=O)C[C@@H](C[C@@H]3C[C@@H](C([C@@](O3)(C[C@@H]4C\/C(=C\/C(=O)OC)\/C[C@@H](O4)\/C=C\/C([C@@]1(O2)O)(C)C)O)(C)C)OC(=O)C)O)[C@@H](C)O,\u003cbr\u003e\nInChi:InChI=1S\/C47H68O17\/c1-10-11-12-13-14-15-39(51)62-43-31(22-41(53)58-9)21-34-25-37(28(2)48)61-42(54)24-32(50)23-35-26-38(59-29(3)49)45(6,7)46(55,63-35)27-36-19-30(20-40(52)57-8)18-33(60-36)16-17-44(4,5)47(43,56)64-34\/h12-17,20,22,28,32-38,43,48,50,55-56H,10-11,18-19,21,23-27H2,1-9H3\/b13-12+,15-14+,17-16+,30-20+,31-22+\/t28-,32-,33+,34+,35-,36+,37-,38+,43+,46+,47-\/m1\/s1,\u003cbr\u003e\nInChiKey:MJQUEDHRCUIRLF-TVIXENOKSA-N,\u003cbr\u003e\nIUPAC Name:[(1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-acetyloxy-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl] (2E,4E)-octa-2,4-dienoate\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nProtein kinase C delta (PKCδ) is a serine\/threonine kinase known for its role in signal transduction processes. Also termed PRKCD PKCδ has a molecular weight of approximately 78-79 kDa. It is widely expressed across various tissues including the brain heart and lung. As a member of the protein kinase C family PKCδ has a specific C1 domain that allows its activation by diacylglycerol (DAG) and bryostatin 1 a known PKCδ activator. The structure of protein kinase C specifically the C4 region plays a critical role in its activity.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPKCδ functions in various cellular processes such as apoptosis cell proliferation and differentiation. It is not part of a fixed protein complex but often interacts with adaptor proteins to execute its functions. PKCδ regulates apoptosis through its action on mitochondrial pathways while its role in cell proliferation involves interactions with specific growth factor receptors.\u003cbr\u003e\nPathways\u003cbr\u003e\nPKCδ integrates into the MAPK and JAK\/STAT pathways. In the MAPK pathway PKCδ collaborates with proteins like ERK to modulate cellular responses to external stimuli. In the JAK\/STAT pathway PKCδ influences gene expression by phosphorylating transcription factors interacting closely with JAK kinases to promote signal transduction.\u003cbr\u003e\nPKCδ is linked to cancer and cardiovascular diseases. Overexpression of PKCδ associates with certain forms of cancer where it influences tumor cell survival and proliferation. In cardiovascular disorders PKCδ mediates processes like cardiomyocyte apoptosis and inflammation. In these contexts PKCδ interacts with proteins such as p53 in cancer progression and Nox2 in cardiovascular diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847491932329,"sku":"ab142262","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab142262","provider":"Iright","version":"1.0","type":"link"}