{"product_id":"abcam-ab142600","title":"Abcam, ab142600, p-Xyleneselenocyanate (1,4-Phenylenebis(methylene)selenocyanate), chemopreventive agent","description":"\u003cp\u003eSize: 100mg\u003cbr\u003e\nMW 314.1 Da, Purity \u0026gt;99%. Potent chemopreventive agent. Inhibits tumorigenesis and carcinogen-induced DNA methylation  in vivo . Orally active.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:85539-83-9,\u003cbr\u003e\nPurity:\u0026gt;99%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:314.1 Da,\u003cbr\u003e\nMolecular formula:C10H8N2Se2,\u003cbr\u003e\nPubChem:5708,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO,\u003cbr\u003e\nBiochemical name:1,4-Phenylenebis(methylene)selenocyanate,\u003cbr\u003e\nBiological description:Potent chemopreventive agent. Inhibits tumorigenesis and carcinogen-induced DNA methylation in vivo. Orally active.,\u003cbr\u003e\nCanonical smiles:C1=CC(=CC=C1C[Se]C#N)C[Se]C#N,\u003cbr\u003e\nInChi:InChI=1S\/C10H8N2Se2\/c11-7-13-5-9-1-2-10(4-3-9)6-14-8-12\/h1-4H,5-6H2,\u003cbr\u003e\nInChiKey:QFTBWTJGZHUOAW-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:[4-(selenocyanatomethyl)phenyl]methyl selenocyanate\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate long-term storage conditions-+4°C, Storage information-The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Cytochrome P450 family members CYP1A1 CYP1A2 and CYP1B1 serve as important enzymes in the metabolism of various xenobiotics and endogenous compounds. They are commonly known as part of the Cytochrome P450 superfamily and each exhibits different substrate specificities. The molecular weight of CYP1B1 for instance is approximately 60 kDa. These enzymes are mainly expressed in the liver but one can also find them in extrahepatic tissues such as the lungs and kidneys.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThese enzymes are involved in the metabolism of carcinogens and drugs playing a role in their activation and detoxification. CYP1A1 CYP1A2 and CYP1B1 help convert procarcinogens into carcinogenic compounds. They do not function in a complex but interact with NADPH-Cytochrome P450 reductase for electron transfer needed in their enzymatic activity.\u003cbr\u003e\nPathways\u003cbr\u003e\nThese enzymes are key players in the aryl hydrocarbon receptor (AhR) signaling pathway. They contribute to the metabolic activation of polycyclic aromatic hydrocarbons. CYP1B1 is particularly associated with the estrogen metabolism pathway wherein it catalyzes hydroxylation reactions. These pathways also include interactions with enzymes like glutathione S-transferases which further process the metabolites produced by CYP1A1 CYP1A2 and CYP1B1.\u003cbr\u003e\nDysregulation of CYP1A1 CYP1A2 and CYP1B1 enzyme activity relates to cancer and cardiovascular diseases. Overexpression or altered activity of these enzymes has correlations with lung cancer due to their role in activating tobacco-related carcinogens. In terms of cardiovascular conditions changes in estrogen metabolism involving CYP1B1 can have implications linking them with vascular diseases. CYP1B1 inhibitors are explored for their potential in chemopreventive strategies targeting these pathways and related protein interactions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847432982697,"sku":"ab142600","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab142600","provider":"Iright","version":"1.0","type":"link"}