{"product_id":"abcam-ab142664","title":"Abcam, ab142664, Tanshinone I, Cytotoxic to cancer cells, inhibits cell migration and invasion","description":"\u003cp\u003eSize: 10mg\u003cbr\u003e\nMW 276.3 Da, Purity \u0026gt;95%. Cytotoxic to cancer cells, inhibits cell migration and invasion. Shows anti-inflammatory, Anticancer, immunosuppressive and anticoagulant agent. Active  in vivo  and  in vitro .\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:568-73-0,\u003cbr\u003e\nPurity:\u0026gt;95%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nSource:Salvia miltiorrhiza Bunge,\u003cbr\u003e\nMolecular weight:276.3 Da,\u003cbr\u003e\nMolecular formula:C18H12O3,\u003cbr\u003e\nPubChem:114917,\u003cbr\u003e\nNature:Native,\u003cbr\u003e\nSolubility:Soluble in DMSO,\u003cbr\u003e\nBiochemical name:Tanshinone I,\u003cbr\u003e\nBiological description:Cytotoxic to cancer cells, inhibits cell migration and invasion. Shows anti-inflammatory, Anticancer, immunosuppressive and anticoagulant agent. Active in vivo and in vitro.,\u003cbr\u003e\nCanonical smiles:CC1=C2C=CC3=C(C2=CC=C1)C(=O)C(=O)C4=C3OC=C4C,\u003cbr\u003e\nInChi:InChI=1S\/C18H12O3\/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14\/h3-8H,1-2H3,\u003cbr\u003e\nInChiKey:AIGAZQPHXLWMOJ-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:1,6-dimethylnaphtho[1,2-g][1]benzofuran-10,11-dione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate long-term storage conditions-+4°C, Storage information-The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTau also known as MAPT (microtubule-associated protein tau) is a protein with a mass of approximately 80 kDa. It primarily stabilizes microtubules in neurons and is found mainly in the brain. SHP-1 also known as PTPN6 (protein tyrosine phosphatase non-receptor type 6) has a mass of about 68 kDa and functions in hematopoietic cells such as lymphocytes and monocytes. CES2 or carboxylesterase 2 weighs around 62 kDa and is expressed predominantly in the liver and digestive tract where it plays a role in drug metabolism.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTau maintains microtubule stability which is essential for neuronal transport and function. Tau does not often form complexes but can be hyperphosphorylated affecting its function. SHP-1 is a cytoplasmic tyrosine phosphatase that regulates signaling pathways in immune cells often being part of larger signaling complexes. CES2 is involved in hydrolyzing ester and amide bonds critical for the detoxification of various substances and metabolism of some prodrugs.\u003cbr\u003e\nPathways\u003cbr\u003e\nTau closely links to the MAPK signaling pathway influencing neuronal growth and differentiation. It interacts with proteins like tubulin in microtubules. SHP-1 is an important regulator in the JAK\/STAT signaling pathway modulating cytokine signaling in immune responses. It interacts with upstream kinases and downstream proteins like STAT. CES2 is integral to the xenobiotic metabolism mechanism playing a part in drug detoxification involving the cytochrome P450 enzymes.\u003cbr\u003e\nTau is significant in neurodegenerative diseases such as Alzheimer's Disease where tau tangles disrupt neuronal function. This connection occurs alongside amyloid-beta proteins. SHP-1 relates to autoimmune diseases affecting the regulation of immune responses due to its role in lymphocyte signaling. CES2 is relevant to drug resistance in cancer as it activates prodrugs used in chemotherapy. In such cases CES2 connects with transport proteins that regulate drug efflux or uptake.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847483248809,"sku":"ab142664","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab142664","provider":"Iright","version":"1.0","type":"link"}