{"product_id":"abcam-ab142698","title":"Abcam, ab142698, RGD (Arg-Gly-Asp), sequence involved in cell adhesion","description":"\u003cp\u003eSize: 5mg \/ 10mg \/ 25mg\u003cbr\u003e\nMW 346.34 Da, Purity \u0026gt;95%. Achieve your results faster with highly validated, pure and trusted compounds.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:99896-85-2,\u003cbr\u003e\nPurity:\u0026gt;95%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:346.34 Da,\u003cbr\u003e\nMolecular formula:C12H22N6O6,\u003cbr\u003e\nPubChem:104802,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in water to 10 mM,\u003cbr\u003e\nBiochemical name:Arginyl-glycyl-aspartic acid,\u003cbr\u003e\nCanonical smiles:C(CC(C(=O)NCC(=O)NC(CC(=O)O)C(=O)O)N)CN=C(N)N,\u003cbr\u003e\nIsomeric smiles:C(C[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)O)N)CN=C(N)N,\u003cbr\u003e\nInChi:InChI=1S\/C12H22N6O6\/c13-6(2-1-3-16-12(14)15)10(22)17-5-8(19)18-7(11(23)24)4-9(20)21\/h6-7H,1-5,13H2,(H,17,22)(H,18,19)(H,20,21)(H,23,24)(H4,14,15,16)\/t6-,7-\/m0\/s1,\u003cbr\u003e\nInChiKey:IYMAXBFPHPZYIK-BQBZGAKWSA-N,\u003cbr\u003e\nIUPAC Name:(2S)-2-[[2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]butanedioic acid\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nIntegrin alpha V also known as CD41 and Integrins beta 3 and beta 5 are transmembrane receptors with different masses according to their subunits. These integrins interact with the extracellular matrix facilitating cell adhesion and signaling. One key feature of these integrins is their binding to the arg-gly-asp (RGD) sequence found in matrix proteins important for cellular attachment. Integrin alpha V has a wide expression in various tissues including endothelial cells osteoclasts and epithelial tissues indicating its role in diverse cellular contexts.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nIntegrins alpha V CD41 beta 3 and beta 5 contribute to cellular processes by forming heterodimers. These complexes participate actively in cell signaling migration and angiogenesis. The arg-gly-asp (RGD) motif serves as an important link between integrins and their matrix ligands impacting interactions with fibronectin and vitronectin. By mediating cellular activities through these complex formations integrins contribute to vital biological functions such as wound healing and tissue remodeling.\u003cbr\u003e\nPathways\u003cbr\u003e\nThese integrins play significant roles in both the PI3K\/AKT and MAPK pathways. These pathways are critical for transmitting signals from the extracellular environment to intracellular effectors influencing cell proliferation survival and mobility. The integrins interact functionally with proteins like focal adhesion kinase (FAK) and Src family kinases which further propagate signaling events. Their involvement in these pathways links them to various cellular responses and physiological processes.\u003cbr\u003e\nIntegrins alpha V and beta 3 are associated with cancer progression and cardiovascular diseases. Their expression and signaling roles contribute to tumor invasion angiogenesis and atherosclerosis development. In cancer these integrins interact with matrix metalloproteinases which degrade extracellular matrix components and facilitate metastasis. Understanding their interactions and pathways offers insight into potential therapeutic targets for treating these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847416271017,"sku":"ab142698","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab142698","provider":"Iright","version":"1.0","type":"link"}