{"product_id":"abcam-ab14387","title":"Abcam, ab14387, Anti-Mus81 antibody [MTA30 2G10\/3]","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nAnti-Mus81 antibody [MTA30 2G10\/3] (ab14387) is a mouse monoclonal antibody detecting Mus81 in  Western Blot, Flow Cytometry . Suitable for  Human . - Over 50 publications - Trusted since 2004\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:MTA30 2G10\/3,\u003cbr\u003e\nIsotype:IgG2a,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow Cyt, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Native Full Length Protein corresponding to Human Crossover junction endonuclease MUS81.Q96NY9\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-Mus81 antibody [MTA30 2G10\/3] (ab14387) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Flow Cyt) in Human samples.\u003cbr\u003e\nWhat is the molecular weight of Mus81?\u003cbr\u003e\nAnti-Mus81 [MTA30 2G10\/3] (ab14387) specifically detects a band for Mus81 (UniProt: Q96NY9) at a molecular weight of 66kDa.\u003cbr\u003e\nTrusted by the scientific community\u003cbr\u003e\nAnti-Mus81 [MTA30 2G10\/3] (ab14387) was first used in a scientific publication in 2004 and has been cited over 50 times in peer-reviewed journals.\u003cbr\u003e\nReviewed by scientists\u003cbr\u003e\nAnti-Mus81 [MTA30 2G10\/3] (ab14387) has over 10 independent reviews from customers.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Purification notes-from TCS, Storage buffer-Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMus81 also known as methyl methanesulfonate 81 plays a significant role in DNA repair and genome stability. As a part of the XPF family of endonucleases Mus81 cuts DNA structures that arise during DNA replication and repair processes. It has a molecular mass of approximately 79 kDa and expresses in a range of organisms including humans. Mus81 is found in tissues with high cell turnover where DNA repair is necessary for maintaining genetic integrity.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMus81 functions as a component of the Mus81-Eme1 complex which facilitates the resolution of DNA junctions such as Holliday junctions stalled replication forks and other intermediates. This activity is important for the successful completion of homologous recombination and DNA repair safeguarding against mutations that may lead to genomic instability. Additionally Mus81 helps maintain the correct number of chromosomes during cell division by preventing or resolving DNA entanglement.\u003cbr\u003e\nPathways\u003cbr\u003e\nMus81 integrates into the pathway coordinating DNA damage response and repair. It is involved in the homologous recombination repair pathway essential for repairing double-strand breaks. Mus81 interacts with proteins such as Rad51 a pivotal protein in the homologous recombination process playing a collaborative role in restructuring damaged DNA. Mus81 provides flexibility and adaptability in orchestrating efficient DNA repair responses through these interactions.\u003cbr\u003e\nMus81 links to cancer progression and genetic disorders where DNA repair is compromised. For instance alterations in Mus81 function can lead to increased susceptibility to cancers due to the buildup of genomic instability. Additionally deficiencies in the Mus81 pathway can contribute to disorders such as Fanconi anemia which involves defective DNA repair. Mus81 also connects with proteins like BRCA2 another critical component in the DNA repair machinery highlighting its potential impact on cancer therapy strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848574554281,"sku":"ab14387","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab14387","provider":"Iright","version":"1.0","type":"link"}