{"product_id":"abcam-ab144370","title":"Abcam, ab144370, Territrem B, AChE inhibitor","description":"\u003cp\u003eSize: 500µg \/ 1mg\u003cbr\u003e\nMW 526.6 Da, Purity \u0026gt;95%. Potent and selective irreversible AChE inhibitor (IC 50  = 8 nM). Binds to the P-site and A-site of AChE. Potentiates ACh-induced neuronal current. Shows antifungal and cholinergic effects  in vivo . Orally active.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:70407-20-4,\u003cbr\u003e\nPurity:\u0026gt;95%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:526.6 Da,\u003cbr\u003e\nMolecular formula:C29H34O9,\u003cbr\u003e\nPubChem:114734,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nBiochemical name:Territrem B,\u003cbr\u003e\nBiological description:Potent and selective irreversible AChE inhibitor (IC50 = 8 nM). Binds to the P-site and A-site of AChE. Potentiates ACh-induced neuronal current. Shows antifungal and cholinergic effects in vivo. Orally active.,\u003cbr\u003e\nCanonical smiles:CC1(C=CC(=O)C2(C1(CCC3(C2(CC4=C(O3)C=C(OC4=O)C5=CC(=C(C(=C5)OC)OC)OC)O)C)O)C)C,\u003cbr\u003e\nIsomeric smiles:C[C@@]12CC[C@@]3([C@@]([C@]1(CC4=C(O2)C=C(OC4=O)C5=CC(=C(C(=C5)OC)OC)OC)O)(C(=O)C=CC3(C)C)C)O,\u003cbr\u003e\nInChi:InChI=1S\/C29H34O9\/c1-25(2)9-8-22(30)27(4)28(25,32)11-10-26(3)29(27,33)15-17-19(38-26)14-18(37-24(17)31)16-12-20(34-5)23(36-7)21(13-16)35-6\/h8-9,12-14,32-33H,10-11,15H2,1-7H3\/t26-,27+,28-,29-\/m1\/s1,\u003cbr\u003e\nInChiKey:PBXNNDFKPQPJBB-VJLHXPKFSA-N,\u003cbr\u003e\nIUPAC Name:(1S,2S,7R,10R)-1,7-dihydroxy-2,6,6,10-tetramethyl-14-(3,4,5-trimethoxyphenyl)-11,15-dioxatetracyclo[8.8.0.02,7.012,17]octadeca-4,12(17),13-triene-3,16-dione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAcetylcholinesterase also known as AChE is an enzyme with a molecular mass of approximately 67 kDa. It plays a critical role in neurotransmission by catalyzing the hydrolysis of the neurotransmitter acetylcholine into acetate and choline. This reaction occurs at neuromuscular junctions and cholinergic synapses therefore terminating synaptic transmission. AChE is highly expressed in muscle and brain tissue particularly in the synaptic cleft where it regulates the nerve signal terminations.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAcetylcholinesterase is essential for maintaining neurotransmission dynamics by ensuring timely acetylcholine breakdown. It does not function as part of a larger enzyme complex but its activity is necessary for efficient synaptic signaling in the nervous system. This enzymatic action prevents continuous stimulation of muscles and nerves by rapidly degrading acetylcholine thereby ensuring proper muscle contraction and cognitive processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nAcetylcholinesterase participates significantly in the cholinergic system. It influences cholinergic signaling pathways by inactivating acetylcholine after its release into the synaptic cleft. This function aligns acetylcholinesterase closely with receptors like nicotinic and muscarinic acetylcholine receptors. It indirectly affects signal transduction pathways that involve these receptors with potential downstream effects on ion channels and intracellular messengers.\u003cbr\u003e\nAcetylcholinesterase plays a significant role in Alzheimer's disease and myasthenia gravis. In Alzheimer's disease decreased acetylcholinesterase function can lead to accumulations of acetylcholine and disrupted signaling contributing to cognitive dysfunction. Acetylcholinesterase inhibitors are therapeutic in such contexts. For myasthenia gravis a disorder affecting neuromuscular transmission the enzyme’s interaction with antibodies targets synaptic acetylcholine receptors. This interaction results in weakened muscle contractions correlating with condition severity.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847474335913,"sku":"ab144370","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab144370","provider":"Iright","version":"1.0","type":"link"}