{"product_id":"abcam-ab144471","title":"Abcam, ab144471, (R)-Flurbiprofen (Tarenflurbil), gamma-secretase inhibitor","description":"\u003cp\u003eSize: 100mg \/ 500mg\u003cbr\u003e\nMW 244.26 Da, Purity \u0026gt;99%. γ-secretase inhibitor. Flurbiprofen (ab142877) enantiomer. Inactive towards COX. Inhibits NF-κB and AP-1 activation. Prevents Aβ42 formation and shows anti-inflammatory and neuroprotective effects  in vivo.  Orally active.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:51543-40-9,\u003cbr\u003e\nPurity:\u0026gt;99%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:244.26 Da,\u003cbr\u003e\nMolecular formula:C15H13FO2,\u003cbr\u003e\nPubChem:92337,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in ethanol to 100 mMSoluble in DMSO to 25 mM,\u003cbr\u003e\nBiochemical name:Tarenflurbil,\u003cbr\u003e\nBiological description:γ-secretase inhibitor. Flurbiprofen (ab142877) enantiomer. Inactive towards COX. Inhibits NF-κB and AP-1 activation. Prevents Aβ42 formation and shows anti-inflammatory and neuroprotective effects in vivo. Orally active.,\u003cbr\u003e\nCanonical smiles:CC(C1=CC(=C(C=C1)C2=CC=CC=C2)F)C(=O)O,\u003cbr\u003e\nIsomeric smiles:C[C@H](C1=CC(=C(C=C1)C2=CC=CC=C2)F)C(=O)O,\u003cbr\u003e\nInChi:InChI=1S\/C15H13FO2\/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11\/h2-10H,1H3,(H,17,18)\/t10-\/m1\/s1,\u003cbr\u003e\nInChiKey:SYTBZMRGLBWNTM-SNVBAGLBSA-N,\u003cbr\u003e\nIUPAC Name:(2R)-2-(3-fluoro-4-phenylphenyl)propanoic acid\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCOX2 also known as Cyclooxygenase 2 and Cytochrome P450 2C19 is an enzyme that has mass approximately 72 kDa. It plays a vital role in converting arachidonic acid to prostaglandins which are lipid compounds that have hormone-like effects. COX2 is inducible and prominently expressed in sites of inflammation epithelial tissues and some cancers. It is not usually present in most normal tissues but becomes highly expressed in response to inflammatory stimuli.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCOX2 is involved in generating prostaglandins influencing inflammation pain and fever response. The enzyme does not typically act alone; it often associates as part of a larger complex that includes other signaling molecules that regulate the conversion of unsaturated fatty acids. This conversion results in substances that can modulate cellular activities such as vasodilation and cellular proliferation. COX2's biological activity links to various body processes that manage inflammation and healing.\u003cbr\u003e\nPathways\u003cbr\u003e\nCOX2 is an important enzyme in the prostaglandin biosynthesis pathway and the inflammatory response pathway. Its activity contributes significantly to the biosynthesis of prostanoids which include prostaglandins and thromboxanes. COX2 interacts with and is regulated by inflammatory and mitogenic signals. It shares roles in these pathways with enzymes like COX1 and it often works in concert with phospholipase A2 which releases arachidonic acid for conversion into prostaglandins.\u003cbr\u003e\nCOX2 is notably implicated in inflammatory diseases such as arthritis and plays a role in cancer where its expression is upregulated. The inflammatory processes it facilitates can exacerbate arthritis symptoms making it a target for nonsteroidal anti-inflammatory drugs like ibuprofen and flurbiprofen. In cancer COX2 is associated with increased angiogenesis and tumor growth. The enzyme's pathway intersects with proteins like matrix metalloproteinases in these disease states showing its role in tissue remodeling and neoplastic progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847497207977,"sku":"ab144471","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab144471","provider":"Iright","version":"1.0","type":"link"}