{"product_id":"abcam-ab144622","title":"Abcam, ab144622, ML-SA1, TRPML agonist","description":"\u003cp\u003eSize: 10mg \/ 50mg\u003cbr\u003e\nMW 362.4 Da, Purity \u0026gt;98%. Selective TRPML agonist. Induces TRPML1, 2 and 3-mediated Ca 2+  release from lysosomes  in vitro . Does not activate TRPM2, TRPV2, TRPA1, TRPV3, TRPC6 channels. Cell-permeable.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:332382-54-4,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:362.4 Da,\u003cbr\u003e\nMolecular formula:C22H22N2O3,\u003cbr\u003e\nPubChem:2880983,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in ethanol to 10 mMSoluble in DMSO to 50 mM,\u003cbr\u003e\nBiochemical name:2-[2-oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione,\u003cbr\u003e\nBiological description:Selective TRPML agonist. Induces TRPML1, 2 and 3-mediated Ca2+ release from lysosomes in vitro. Does not activate TRPM2, TRPV2, TRPA1, TRPV3, TRPC6 channels. Cell-permeable.,\u003cbr\u003e\nCanonical smiles:CC1CC(N(C2=CC=CC=C12)C(=O)CN3C(=O)C4=CC=CC=C4C3=O)(C)C,\u003cbr\u003e\nInChi:InChI=1S\/C22H22N2O3\/c1-14-12-22(2,3)24(18-11-7-6-8-15(14)18)19(25)13-23-20(26)16-9-4-5-10-17(16)21(23)27\/h4-11,14H,12-13H2,1-3H3,\u003cbr\u003e\nInChiKey:KDDHBJICVBONAX-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:2-[2-oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1-yl)ethyl]isoindole-1,3-dione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTRPC4 also known as Transient Receptor Potential Cation Channel Subfamily C Member 4 plays an important mechanical role as a non-selective cation channel that conducts calcium and sodium ions into cells. This protein has a molecular weight of approximately 100 kDa. TRPC4 is highly expressed in various tissues including the brain heart lung and kidney. Its presence in these tissues suggests an important role in multiple physiological processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTRPC4 influences cellular calcium signaling impacting a variety of physiological responses such as vasodilation and neurotransmission. TRPC4 can form both homo- and heteromeric complexes often associating with other TRPC family members. Through these complexes TRPC4 contributes to cellular responses to neurotransmitters and other signaling molecules indicating its role in a wide range of cellular functions.\u003cbr\u003e\nPathways\u003cbr\u003e\nTRPC4 participates in the phospholipase C (PLC) signaling pathway which regulates important cellular functions such as cell proliferation and differentiation. TRPC4 is related to G-protein coupled receptors (GPCRs) within this pathway facilitating the relay of extracellular signals through PLC activation and subsequent calcium influx. Additionally TRPC4 interacts with proteins like calmodulin which modulates its activity and impacts calcium-related signaling pathways.\u003cbr\u003e\nTRPC4's dysregulation associates with cardiovascular diseases and anxiety disorders. The aberrant calcium entry through TRPC4 channels can lead to pathological conditions such as hypertension and heart failure. During stress responses the interaction between TRPC4 and CRHR2 the corticotropin-releasing hormone receptor 2 may affect anxiety-related behaviors hinting at TRPC4’s involvement in psychiatric disorders. By influencing these pathways TRPC4 emerges as a potential therapeutic target for managing such conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847425151145,"sku":"ab144622","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab144622","provider":"Iright","version":"1.0","type":"link"}