{"product_id":"abcam-ab145052","title":"Abcam, ab145052, Aminopurvalanol A, cyclin-dependent kinase inhibitor","description":"\u003cp\u003eSize: 10mg \/ 50mg\u003cbr\u003e\nMW 403.9 Da, Purity \u0026gt;99%. Potent, cell-permeable cyclin-dependent kinase inhibitor (IC 50  values are 33 (cdk1\/cyclin B), 33 (cdk2\/cyclin A), 28 (cdk2\/cyclin E) and 20 nM (cdk5\/p35)). Inhibits ERK1 (IC 50  = 12.0 μM) and ERK2 (IC 50  = 3.1 μM). Induces cell cycle arrest at G 2 \/M phase (IC 50  = 1.25 μM). Shows apoptotic effects.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:220792-57-4,\u003cbr\u003e\nPurity:\u0026gt;99%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:403.9 Da,\u003cbr\u003e\nMolecular formula:C19H26ClN7O,\u003cbr\u003e\nPubChem:6604931,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in ethanol to 50 mMSoluble in DMSO to 100 mM,\u003cbr\u003e\nBiochemical name:aminopurvalanol A,\u003cbr\u003e\nBiological description:Potent, cell-permeable cyclin-dependent kinase inhibitor (IC50 values are 33 (cdk1\/cyclin B), 33 (cdk2\/cyclin A), 28 (cdk2\/cyclin E) and 20 nM (cdk5\/p35)). Inhibits ERK1 (IC50 = 12.0 μM) and ERK2 (IC50 = 3.1 μM). Induces cell cycle arrest at G2\/M phase (IC50 = 1.25 μM). Shows apoptotic effects.,\u003cbr\u003e\nCanonical smiles:CC(C)C(CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NC3=CC(=CC(=C3)N)Cl,\u003cbr\u003e\nIsomeric smiles:CC(C)[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NC3=CC(=CC(=C3)N)Cl,\u003cbr\u003e\nInChi:InChI=1S\/C19H26ClN7O\/c1-10(2)15(8-28)24-19-25-17(23-14-6-12(20)5-13(21)7-14)16-18(26-19)27(9-22-16)11(3)4\/h5-7,9-11,15,28H,8,21H2,1-4H3,(H2,23,24,25,26)\/t15-\/m0\/s1,\u003cbr\u003e\nInChiKey:RAMROQQYRRQPDL-HNNXBMFYSA-N,\u003cbr\u003e\nIUPAC Name:(2R)-2-[[6-(3-amino-5-chloroanilino)-9-propan-2-ylpurin-2-yl]amino]-3-methylbutan-1-ol\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-The product can be stored for up to 12 months\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847456641193,"sku":"ab145052","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab145052","provider":"Iright","version":"1.0","type":"link"}