{"product_id":"abcam-ab145056","title":"Abcam, ab145056, SU 5416 (Semaxanib), VEGFR-2 inhibitor","description":"\u003cp\u003eSize: 10mg \/ 50mg\u003cbr\u003e\nMW 238.28 Da, Purity \u0026gt;99%. Selective VEGFR-2 inhibitor. Adenine mimetic. Inhibits endothelial cell proliferation. Inhibits angiogenesis and shows antitumor effects  in vivo.  .\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:194413-58-6,\u003cbr\u003e\nPurity:\u0026gt;99%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:238.28 Da,\u003cbr\u003e\nMolecular formula:C15H14N2O,\u003cbr\u003e\nPubChem:5329098,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in ethanol to 10 mMSoluble in DMSO to 100 mM,\u003cbr\u003e\nBiochemical name:Semaxanib,\u003cbr\u003e\nBiological description:Selective VEGFR-2 inhibitor. Adenine mimetic. Inhibits endothelial cell proliferation. Inhibits angiogenesis and shows antitumor effects in vivo.,\u003cbr\u003e\nCanonical smiles:CC1=CC(=C(N1)C=C2C3=CC=CC=C3NC2=O)C,\u003cbr\u003e\nIsomeric smiles:CC1=CC(=C(N1)\/C=C\\2\/C3=CC=CC=C3NC2=O)C,\u003cbr\u003e\nInChi:InChI=1S\/C15H14N2O\/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18\/h3-8,16H,1-2H3,(H,17,18)\/b12-8-,\u003cbr\u003e\nInChiKey:WUWDLXZGHZSWQZ-WQLSENKSSA-N,\u003cbr\u003e\nIUPAC Name:(3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe VEGF receptors—VEGF Receptor 1 (Flt-1) VEGF Receptor 2 (KDR\/Flk-1) and VEGF Receptor 3 (Flt-4)—are tyrosine kinase receptors that mediate vascular endothelial growth factor (VEGF) signaling. These receptors vary in molecular mass with VEGF Receptor 1 being approximately 180 kDa VEGF Receptor 2 about 200 - 210 kDa and VEGF Receptor 3 around 195 - 200 kDa. They are expressed on the surface of various cells primarily vascular endothelial cells where they regulate different functions related to angiogenesis and lymphangiogenesis.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThese receptors play roles in modulating vascular permeability endothelial cell proliferation and blood vessel formation. They are part of complexes that include ligands such as various VEGF isoforms. VEGF Receptor 2 is the principal mediator of VEGF-induced endothelial cell responses. VEGF Receptor 1 serves as a decoy receptor to modulate the availability of VEGF for VEGF Receptor 2 whilst VEGF Receptor 3 mainly regulates lymphatic endothelial cell functions.\u003cbr\u003e\nPathways\u003cbr\u003e\nThese receptors are central to the VEGF signaling pathway which plays a role in angiogenesis and vasculogenesis. The pathway involves a cascade where VEGF binding leads to receptor dimerization and phosphorylation of intracellular domains activating downstream pathways like the MAPK and PI3K\/Akt pathways. These receptors interact with various proteins including growth factors and other signaling molecules to ensure proper vascular function and adaptation.\u003cbr\u003e\nDysregulation of VEGF receptor signaling is implicated in cancer and retinal diseases. Overexpression or aberrant activation of VEGF Receptor 2 in particular is associated with tumor-induced angiogenesis allowing tumors to grow their own blood supply. In eye diseases like age-related macular degeneration improper VEGF signaling contributes to abnormal blood vessel formation. Other proteins such as neuropilins modulate these interactions serving as co-receptors to alter binding affinity and signaling output in disease contexts.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847425216681,"sku":"ab145056","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab145056","provider":"Iright","version":"1.0","type":"link"}