{"product_id":"abcam-ab145190","title":"Abcam, ab145190, MMP-2\/MMP-9 Inhibitor I, MMP-2\/MMP-9 inhibitor","description":"\u003cp\u003eSize: 5mg\u003cbr\u003e\nMW 381.4 Da, Purity \u0026gt;99%. Matrix metalloproteinase inhibitor of MMP-2\/MMP-9. Synergizes with TNF-α to induce apoptosis in cancer cells. Active  in vitro .\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:193807-58-8,\u003cbr\u003e\nPurity:\u0026gt;99%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:381.4 Da,\u003cbr\u003e\nMolecular formula:C21H19NO4S,\u003cbr\u003e\nPubChem:10667540,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 25 mM,\u003cbr\u003e\nBiochemical name:Mmp-2\/mmp-9 inhibitor i,\u003cbr\u003e\nBiological description:Matrix metalloproteinase inhibitor of MMP-2\/MMP-9. Synergizes with TNF-α to induce apoptosis in cancer cells. Active in vitro.,\u003cbr\u003e\nCanonical smiles:C1=CC=C(C=C1)CC(C(=O)O)NS(=O)(=O)C2=CC=C(C=C2)C3=CC=CC=C3,\u003cbr\u003e\nIsomeric smiles:C1=CC=C(C=C1)C[C@H](C(=O)O)NS(=O)(=O)C2=CC=C(C=C2)C3=CC=CC=C3,\u003cbr\u003e\nInChi:InChI=1S\/C21H19NO4S\/c23-21(24)20(15-16-7-3-1-4-8-16)22-27(25,26)19-13-11-18(12-14-19)17-9-5-2-6-10-17\/h1-14,20,22H,15H2,(H,23,24)\/t20-\/m1\/s1,\u003cbr\u003e\nInChiKey:JBYHBQIDTNHWJF-HXUWFJFHSA-N,\u003cbr\u003e\nIUPAC Name:(2R)-3-phenyl-2-[(4-phenylphenyl)sulfonylamino]propanoic acid\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMatrix metalloproteinases MMP-2 and MMP-9 also known as gelatinase A and gelatinase B play key roles in cellular processes by degrading components of the extracellular matrix. MMP-2 has a mass of approximately 72 kDa while MMP-9 is around 92 kDa. These proteins are expressed in various tissues including the heart lungs and reproductive organs. Their expression levels often increase in response to cytokines and growth factors highlighting their involvement in tissue remodeling.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMMPs facilitate processes such as angiogenesis cell migration and wound healing through the digestion of collagen and gelatin in the extracellular matrix. MMP-2 and MMP-9 act within a proteinase complex allowing for specific substrate targeting and regulatory control. They fine-tune cellular environments by modulating interstitial barriers impacting both normal and pathological conditions.\u003cbr\u003e\nPathways\u003cbr\u003e\nMMP-2 and MMP-9 are essential participants in the MAPK and PI3K\/Akt signaling pathways. They coordinate with proteins like TIMPs (tissue inhibitors of metalloproteinases) to regulate matrix turnover and cellular proliferation. This involvement highlights their necessity in transducing extracellular signals that influence gene expression and cell behavior.\u003cbr\u003e\nMMP-2 and MMP-9 contribute to pathological states like cancer metastasis and cardiovascular diseases. During cancer progression these proteins assist in tumor invasion by remodeling tissues often working with other proteins such as VEGF (vascular endothelial growth factor). In cardiovascular diseases they disrupt normal myocardial architecture affecting heart function and collaborating with inflammatory cytokines in tissue damage pathways.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847420268713,"sku":"ab145190","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab145190","provider":"Iright","version":"1.0","type":"link"}