{"product_id":"abcam-ab145630","title":"Abcam, ab145630, Cancer cell stemness inhibitor (Napabucasin), high-cancer cell inhibitor","description":"\u003cp\u003eSize: 5mg\u003cbr\u003e\nMW 240.21 Da, Purity \u0026gt;98%. Potent, broad spectrum stemness high-cancer cell inhibitor (IC 50  values are 500 - 1200 nM). Inhibits STAT3-driven gene transcription. Potently prevents self-renewal in cancer stem cells. Shows antineoplastic and antimetastatic effects  in vivo.  Orally active.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:83280-65-3,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:240.21 Da,\u003cbr\u003e\nMolecular formula:C14H8O4,\u003cbr\u003e\nPubChem:10331844,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO,\u003cbr\u003e\nBiochemical name:Napabucasin,\u003cbr\u003e\nBiological description:Potent, broad spectrum stemness high-cancer cell inhibitor (IC50 values are 500 - 1200 nM). Inhibits STAT3-driven gene transcription. Potently prevents self-renewal in cancer stem cells. Shows antineoplastic and antimetastatic effects in vivo. Orally active.,\u003cbr\u003e\nCanonical smiles:CC(=O)C1=CC2=C(O1)C(=O)C3=CC=CC=C3C2=O,\u003cbr\u003e\nInChi:InChI=1S\/C14H8O4\/c1-7(15)11-6-10-12(16)8-4-2-3-5-9(8)13(17)14(10)18-11\/h2-6H,1H3,\u003cbr\u003e\nInChiKey:DPHUWDIXHNQOSY-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:2-acetylbenzo[f][1]benzofuran-4,9-dione\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called 2476 Cancer Cell Stemness Inhibitor I. 2476-5 is the same size as the 5 mg size of ab145630.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSTAT3 also known as Signal Transducer and Activator of Transcription 3 is a transcription factor involved in various cellular activities such as cell growth and survival. It weighs approximately 92 kDa and is expressed in a wide range of tissues including the liver immune cells and the brain. STAT3 becomes activated through phosphorylation in response to cytokine signaling and forms dimers that translocate to the cell nucleus where it binds DNA to regulate gene expression.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSTAT3 plays a role in mediating responses to extracellular stimuli like cytokines and growth factors. It is part of the JAK-STAT signaling pathway complex where it acts as an important regulator of gene expression involved in immune functions cell proliferation and apoptosis. STAT3's ability to modulate these biological functions makes it integral in maintaining tissue homeostasis and responding to environmental changes.\u003cbr\u003e\nPathways\u003cbr\u003e\nSTAT3 is essential in the JAK-STAT pathway and the MAPK pathway. It interacts with several proteins such as Janus kinases (JAKs) in response to cytokines which further regulate transcriptional responses. The interplay with proteins like ERK in the MAPK pathway highlights STAT3's versatility in controlling diverse cellular processes from inflammation to growth and development.\u003cbr\u003e\nSTAT3 is implicated in cancer and autoimmune diseases due to its roles in regulating cell proliferation and immune responses. For cancers STAT3 interaction with other oncogenic proteins like BCL-XL contributes to tumor survival and growth. In autoimmune disorders its dysregulation can result in aberrant immune activity. Notably its association with Interferon beta in antiviral responses demonstrates the breadth of its clinical relevance.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847481544873,"sku":"ab145630","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab145630","provider":"Iright","version":"1.0","type":"link"}