{"product_id":"abcam-ab146128","title":"Abcam, ab146128, cis-ACBD (1-Aminocyclobutane-1,3-dicarboxylic acid), L-glutamate uptake inhibitor","description":"\u003cp\u003eSize: 10mg \/ 50mg\u003cbr\u003e\nMW 159.14 Da. Selective, competitive L-glutamate uptake inhibitor (IC 50  = 30 μM). Increases basal and potassium evoked D-aspartate release.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:73550-55-7,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:159.14 Da,\u003cbr\u003e\nMolecular formula:C6H9NO4,\u003cbr\u003e\nPubChem:1214,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in 1eq. NaOH to 50 mM,\u003cbr\u003e\nBiochemical name:1-Aminocyclobutane-1,3-dicarboxylic acid,\u003cbr\u003e\nBiological description:Selective, competitive L-glutamate uptake inhibitor (IC50 = 30 μM). Increases basal and potassium evoked D-aspartate release.,\u003cbr\u003e\nCanonical smiles:C1C(CC1(C(=O)O)N)C(=O)O,\u003cbr\u003e\nInChi:InChI=1S\/C6H9NO4\/c7-6(5(10)11)1-3(2-6)4(8)9\/h3H,1-2,7H2,(H,8,9)(H,10,11),\u003cbr\u003e\nInChiKey:GGMYWPBNZXRMME-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:1-aminocyclobutane-1,3-dicarboxylic acid\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-Ambient, Appropriate long-term storage conditions-Ambient, Storage information-The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe N-methyl-D-aspartate (NMDA) receptors also known as NMDAR2A NMDAR2B GluN2C NMDAR1 NMDAR3A + 3B and GluN2D are types of glutamate receptors that are key players in synaptic transmission and plasticity. These receptors are tetrameric composed of different combinations of subunits that weigh approximately 135–175 kDa. They are primarily expressed in the central nervous system specifically in the brain regions such as the hippocampus and the cortex where they mediate excitatory synaptic transmission.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNMDA receptors function as part of a larger receptor complex on the cell membrane playing a critical role in learning and memory. They act by permitting the flow of calcium ions into the neuron when activated by the neurotransmitter glutamate in conjunction with membrane depolarization. This ion influx triggers downstream signaling pathways that lead to long-term potentiation (LTP) a mechanism for synaptic strengthening.\u003cbr\u003e\nPathways\u003cbr\u003e\nNMDA receptors are essential components of the glutamatergic signaling pathway. They participate in the calcium\/calmodulin-dependent protein kinase (CaMK) pathway and interact with other proteins such as PSD-95 which organizes receptor complexes in the synapse. The pathways coordinate to modulate synaptic plasticity important for processes like neuronal development and adult neurogenesis.\u003cbr\u003e\nNMDA receptors have strong links to conditions such as schizophrenia and Alzheimer's disease. Anomalies in NMDA receptor function can lead to disrupted synaptic transmission and cognitive defects associated with these diseases. For example in schizophrenia altered NMDA receptor activity may influence other associated proteins like dopamine receptors contributing to the disease's pathophysiology.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847484362921,"sku":"ab146128","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab146128","provider":"Iright","version":"1.0","type":"link"}