{"product_id":"abcam-ab14685","title":"Abcam, ab14685, Anti-SGLT1 antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nRabbit Polyclonal SGLT1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 27 publications. Immunogen corresponding to Synthetic Peptide within Human SLC5A1 aa 600-650.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human SLC5A1 aa 600-650. The exact immunogen used to generate this antibody is proprietary information.P13866,\u003cbr\u003e\nSpecificity:The immunogen used for this product shares 75% homology with SGLT5. Cross-reactivity with this protein has not been confirmed experimentally.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-Preservative: 0.02% Sodium azideConstituents: HEPES, Tris glycine, 30% Glycerol (glycerin, glycerine), 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSGLT1 also known as sodium\/glucose cotransporter 1 or SLC5A1 is a membrane protein actively responsible for glucose and galactose uptake in the small intestine and renal tubules. It has a molecular mass of approximately 73 kDa. Expressed mainly in the brush border of the enterocytes in the small intestinal lining and to a lesser degree in the kidney SGLT1 functions by coupling the transport of glucose to sodium ions' electrochemical gradient enabling effective nutrient absorption.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSGLT1's main role is in facilitating nutrient absorption in the gastrointestinal tract. It operates as part of the larger SGLT protein family but does not form a complex with other proteins. The protein is essential for the transport of monosaccharides from the gut into circulation. By ensuring glucose and galactose absorption during digestive processes SGLT1 provides necessary carbohydrates for cellular metabolism and systemic energy homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe transport protein SGLT1 is integral to the glucose uptake pathway. This pathway intersects with the insulin signaling pathway because the glucose absorbed by SGLT1 later enters systemic circulation. SGLT1 also complements the GLUT family of transporters especially GLUT2 which function downstream by facilitating glucose transport across the intestinal basolateral membrane into the bloodstream. The interplay between these transport mechanisms maintains glucose levels post-ingestion.\u003cbr\u003e\nSGLT1 dysfunction is linked to glucose-galactose malabsorption a genetic disorder causing severe dehydration and diarrhea due to glucose and galactose accumulation in the lumen. Additionally research investigates SGLT1's contribution to diabetes management given its role in glucose absorption. The protein's activity along with related proteins like GLUT2 and GLUT4 could influence insulin resistance and glucose homeostasis in metabolic syndromes. Understanding SGLT1 in these contexts enables potential therapeutic interventions for conditions involving disordered glucose metabolism.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848645398697,"sku":"ab14685","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab14685","provider":"Iright","version":"1.0","type":"link"}