{"product_id":"abcam-ab146969","title":"Abcam, ab146969, UC2288, p21 inhibitor","description":"\u003cp\u003eSize: 5mg \/ 10mg \/ 25mg\u003cbr\u003e\nMW 481.8 Da, Purity \u0026gt;98%. Cell-permeable, phenylcyclohexyl-urea based compound that selectively downregulates the expression of p21, independent of p53 expression, at either transcription or post-transcriptional level. Attenuates p21 protein levels with minimal effect on p21 protein stability. Has no significant effect on the activities of Raf kinases, VEGFR2 kinase, or the phosphorylation state of ERK. Effectively inhibits the growth of multiple cancer cell lines (GI 50  = ~ 10 μM against NCI60 cell lines).\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:1394011-91-6,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:481.8 Da,\u003cbr\u003e\nMolecular formula:C20H18ClF6N3O2,\u003cbr\u003e\nPubChem:60196635,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in ethanol to 100 mMSoluble in DMSO to 100 mM,\u003cbr\u003e\nBiochemical name:1-[4-Chloro-3-(trifluoromethyl)phenyl]-3-[(1r,4r)-4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}cyclohexyl]urea,\u003cbr\u003e\nBiological description:Cell-permeable, phenylcyclohexyl-urea based compound that selectively downregulates the expression of p21, independent of p53 expression, at either transcription or post-transcriptional level. Attenuates p21 protein levels with minimal effect on p21 protein stability. Has no significant effect on the activities of Raf kinases, VEGFR2 kinase, or the phosphorylation state of ERK. Effectively inhibits the growth of multiple cancer cell lines (GI50 = ~ 10 μM against NCI60 cell lines).,\u003cbr\u003e\nCanonical smiles:C1CC(CCC1NC(=O)NC2=CC(=C(C=C2)Cl)C(F)(F)F)OC3=NC=C(C=C3)C(F)(F)F,\u003cbr\u003e\nInChi:InChI=1S\/C20H18ClF6N3O2\/c21-16-7-4-13(9-15(16)20(25,26)27)30-18(31)29-12-2-5-14(6-3-12)32-17-8-1-11(10-28-17)19(22,23)24\/h1,4,7-10,12,14H,2-3,5-6H2,(H2,29,30,31),\u003cbr\u003e\nInChiKey:ISPSOOYSNVVMMB-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[4-[5-(trifluoromethyl)pyridin-2-yl]oxycyclohexyl]urea\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store in the dark\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847422824617,"sku":"ab146969","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab146969","provider":"Iright","version":"1.0","type":"link"}