{"product_id":"abcam-ab147471","title":"Abcam, ab147471, MLi-2, LRRK2 inhibitor (DMSO solution)","description":"\u003cp\u003eSize: 1mg\u003cbr\u003e\nMW 379.5 Da, Purity \u0026gt;98%. Potent and selective LRRK2 inhibitor. Inhibits LRRK2 in cell-free (IC 50  = 0.76 nM), cell-based (IC 50  = 1.4 nM) and radioligand-binding (IC 50  = 3.4 nM) assays. Greater than 295-fold selective against a panel of receptors, channels and over 300 kinases. Oral dosing results in reduced Ser935 phosphorylation of LRRK2 in animal models.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:1627091-47-7,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nMolecular weight:379.5 Da,\u003cbr\u003e\nMolecular formula:C21H25N5O2,\u003cbr\u003e\nPubChem:78319901,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nBiochemical name:MLi-2-Bio-X,\u003cbr\u003e\nBiological description:Potent and selective LRRK2 inhibitor. Inhibits LRRK2 in cell-free (IC50 = 0.76 nM), cell-based (IC50 = 1.4 nM) and radioligand-binding (IC50 = 3.4 nM) assays. Greater than 295-fold selective against a panel of receptors, channels and over 300 kinases. Oral dosing results in reduced Ser935 phosphorylation of LRRK2 in animal models.,\u003cbr\u003e\nCanonical smiles:CC1CN(CC(O1)C)C2=NC=NC(=C2)C3=NNC4=C3C=C(C=C4)OC5(CC5)C,\u003cbr\u003e\nIsomeric smiles:C[C@@H]1CN(C[C@@H](O1)C)C2=NC=NC(=C2)C3=NNC4=C3C=C(C=C4)OC5(CC5)C,\u003cbr\u003e\nInChi:InChI=1S\/C21H25N5O2\/c1-13-10-26(11-14(2)27-13)19-9-18(22-12-23-19)20-16-8-15(28-21(3)6-7-21)4-5-17(16)24-25-20\/h4-5,8-9,12-14H,6-7,10-11H2,1-3H3,(H,24,25)\/t13-,14+,\u003cbr\u003e\nInChiKey:ATUUNJCZCOMUKD-OKILXGFUSA-N,\u003cbr\u003e\nIUPAC Name:(2R,6S)-2,6-dimethyl-4-[6-[5-(1-methylcyclopropyl)oxy-1H-indazol-3-yl]pyrimidin-4-yl]morpholine\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847496159401,"sku":"ab147471","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab147471","provider":"Iright","version":"1.0","type":"link"}