{"product_id":"abcam-ab150424","title":"Abcam, ab150424, Anti-HERPUD1 antibody [EPR9649]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal HERPUD1 antibody. Suitable for WB, ICC\/IF, Flow Cyt (Intra) and reacts with Human samples. Cited in 11 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR9649,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IF, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHERPUD1 also known as Herp is a protein involved in the cellular response to stress especially related to the endoplasmic reticulum (ER). It has a molecular mass of approximately 42 kDa. This protein is expressed in various tissues with high expression levels found in the liver heart and muscle. HERPUD1 becomes particularly upregulated during conditions that cause ER stress helping cells manage misfolded proteins.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nHERPUD1 helps maintain cellular homeostasis during periods of ER stress by facilitating the degradation of misfolded proteins. It forms part of a larger complex in the ER-associated degradation (ERAD) pathway which targets these proteins for retrotranslocation and subsequent destruction by the proteasome. HERPUD1 therefore plays a vital role in mitigating the buildup of potentially harmful proteins within the cell.\u003cbr\u003e\nPathways\u003cbr\u003e\nHERPUD1 is integral to the unfolded protein response (UPR) and the ERAD pathway. In the UPR HERPUD1 is involved in signaling mechanisms that help restore normal ER function. It interacts with other proteins such as SEL1L and DERLIN-1 within the ERAD pathway to ensure the proper disposal of misfolded proteins preventing cellular damage.\u003cbr\u003e\nHERPUD1 is connected with neurodegenerative diseases and cardiac disorders. Its dysfunction or dysregulation can lead to the accumulation of misfolded proteins contributing to conditions like Alzheimer's disease. Moreover HERPUD1's relationship with proteins such as ubiquitin suggests its involvement in cardiac stress responses which can be significant in heart failure. HERPUD1's functions and interactions underline its importance in cellular stress responses and associated disease states.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855864778921,"sku":"ab150424","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab150424","provider":"Iright","version":"1.0","type":"link"}