{"product_id":"abcam-ab150659","title":"Abcam, ab150659, Anti-Tyrosine Hydroxylase antibody [TOH A1.1] - Neuronal Marker","description":"\u003cp\u003eSize: 250µL \/ 500µL\u003cbr\u003e\nMouse Monoclonal Tyrosine Hydroxylase antibody. Suitable for EM, ICC\/IF, IHC-Fr and reacts with Rat samples. Cited in 6 publications. Immunogen corresponding to Native Full Length Protein corresponding to Rat TH.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:TOH A1.1,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Rat,\u003cbr\u003e\nApplications:ICC\/IF, IHC-Fr, EMSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Native Full Length Protein corresponding to Rat TH.P04177,\u003cbr\u003e\nSpecificity:The antibody recognizes the full length TOH\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab150659 reacts with tyrosine hydroxylase immunoreactive sites in the known catecholaminergic neurons and and fibre systems of rat brain. It recognizes best the configuration of tyrosine hydroxylase in fixed tissues.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Lyophilized protein G purified in PBS pH7.4, Storage buffer-Constituents: 99% Water, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTyrosine hydroxylase also known as TH is an enzyme that catalyzes the conversion of L-tyrosine to L-DOPA. It weighs approximately 60 kDa. You can find this enzyme expressed mainly in the brain adrenal glands and some peripheral tissues. Commonly studied antibodies include anti-tyrosine hydroxylase or anti-TH. It plays a significant role in the catecholamine biosynthesis pathway serving as the rate-limiting step in dopamine synthesis.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTyrosine hydroxylase is essential for synthesizing catecholamines including dopamine norepinephrine and epinephrine. This enzyme associates with other components in the catecholamine biosynthetic pathway. It functions as part of a larger complex within certain cells where its action determines levels of important neurotransmitters. These neurotransmitters help regulate numerous central and peripheral nervous system activities.\u003cbr\u003e\nPathways\u003cbr\u003e\nTyrosine hydroxylase acts as a critical component in both the dopaminergic and adrenergic pathways. In the dopaminergic pathway tyrosine hydroxylase facilitates dopamine production influencing various physiological processes. The enzyme also correlates with ardrd protein in these pathways allowing fine-tuned control of neurotransmitter synthesis. Proteins related to tyrosine hydroxylase in these pathways include aromatic L-amino acid decarboxylase which further processes L-DOPA into dopamine.\u003cbr\u003e\nTyrosine hydroxylase has connections with neurodegenerative diseases like Parkinson's disease and conditions such as dystonia. Dysfunctional expression or activity of this enzyme can lead to dopamine deficiency contributing to the motor symptoms in Parkinson's disease. In dystonia alterations in tyrosine hydroxylase activity affect neurotransmitter balance influencing muscle coordination. The relationship with ardrd protein highlights tyrosine hydroxylase's role in maintaining neural health and it highlights potential areas for therapeutic intervention.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860503482537,"sku":"ab150659","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab150659","provider":"Iright","version":"1.0","type":"link"}