{"product_id":"abcam-ab15123","title":"Abcam, ab15123, Anti-Aquaporin 7 antibody","description":"\u003cp\u003eSize: 25µL\u003cbr\u003e\nChicken Polyclonal Aquaporin 7 antibody. Suitable for ELISA, WB, ICC\/IF and reacts with Rat samples. Cited in 4 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Chicken,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgY,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Rat,\u003cbr\u003e\nApplications:WB, ELISA, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Rat Aquaporin-7. The exact immunogen used to generate this antibody is proprietary information.P56403\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nPurity-Whole antiserum, Shipped at conditions-Blue Ice, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAquaporin 7 (AQP7) sometimes referred to as AQPap is a protein channel that enables the transport of water and small molecules like glycerol across cell membranes. It has a molecular mass of approximately 28 kDa. This protein is widely expressed in adipose tissue kidney and testis where it facilitates critical cellular processes by regulating water and solute flow. The localization of AQP7 in these tissues highlights its key role in the body’s fluid management and metabolic regulation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAQP7 plays an important role in maintaining the balance of glycerol and water within cells which is essential for energy homeostasis. It does not function as part of a known complex but works as an individual tetrameric channel. In adipose tissue AQP7 facilitates the release of glycerol consequently affecting lipid metabolism and energy storage. This function contributes significantly to how organisms respond to energy demands and metabolic changes.\u003cbr\u003e\nPathways\u003cbr\u003e\nAQP7 is critical in glycerol transport and lipid metabolism pathways impacting insulin signaling and glucose regulation. AQP7 is closely associated with proteins like adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) which regulate lipid breakdown and mobilization. The interplay between these proteins and AQP7 illustrates its importance in pathways that govern energy balance and metabolic flexibility affecting how cells use stored energy.\u003cbr\u003e\nAQP7 has associations with metabolic conditions such as obesity and type 2 diabetes. Altered expression or functionality of AQP7 in adipose tissue can influence glycerol release and consequently lipid and glucose metabolism. Dysregulation of AQP7 may also impact metabolic processes by interacting with proteins involved in lipid metabolism like ATGL and HSL. These connections highlight the significance of AQP7 in understanding the molecular basis of metabolic diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850121859241,"sku":"ab15123","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab15123","provider":"Iright","version":"1.0","type":"link"}