{"product_id":"abcam-ab151692","title":"Abcam, ab151692, Anti-EAF2 antibody [EPR7117(2)]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal EAF2 antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 4 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR7117(2),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nEAF2 also known as ELL-associated factor 2 plays an important role in transcription regulation. This protein weighing approximately 32 kDa interacts with the ELL (eleven-nineteen lysine-rich leukemia) family of RNA polymerase II elongation factors. EAF2 expression is noted in various tissues including the prostate colon and liver indicating a broad impact on cellular functions across the body. Researchers often study EAF2 for its regulatory abilities and its influence on gene expression.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nEAF2 regulates the transcription elongation process. It works as part of a complex with ELL proteins impacting the rate at which RNA polymerase II can transcribe genetic information into messenger RNA. The EAF2-ELL complex stabilizes and enhances the transcription process ensuring proper gene expression and cellular function. Its influence on transcription shapes how cells respond to their environment making EAF2 a protein of interest in many studies.\u003cbr\u003e\nPathways\u003cbr\u003e\nEAF2 significantly impacts the androgen receptor signaling pathway and transcriptional regulation pathways. In the androgen receptor pathway EAF2 influences gene expression by modulating the activity of this receptor affecting processes such as cell growth and differentiation. Furthermore it interacts with other proteins within these pathways including androgen receptor itself and transcriptional machinery components like RNA polymerase II linking it to cellular proliferation and hormone response.\u003cbr\u003e\nEAF2 has a connection to prostate cancer and chronic liver disease. Its role in prostate cancer stems from its involvement in androgen receptor pathways where aberrant expression or dysfunction might contribute to tumor development and progression. EAF2 interacts with other proteins like ELL and androgen receptors making it a potential target for cancer therapy. In chronic liver disease understanding EAF2's contributions to transcription regulation might reveal its role in liver physiology and pathology providing insights into disease mechanisms and potential treatment strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850436759721,"sku":"ab151692","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab151692","provider":"Iright","version":"1.0","type":"link"}