{"product_id":"abcam-ab151729","title":"Abcam, ab151729, Anti-Arp3 antibody [EPR10428(B)]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal ARP3 antibody. Suitable for IHC-P, WB and reacts with Mouse, Human, Rat samples. Cited in 4 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR10428(B),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nArp3 also known as Actin-related protein 3 is an important component of the human cellular cytoskeleton machinery. It has a molecular mass of approximately 47 kDa and is ubiquitously expressed across various tissues. Arp3 participates in the nucleation and branching of actin filaments acting mechanically to control the structural organization of the cytoskeleton. This protein is highly conserved across species which shows its important role in fundamental cellular processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nArp3 plays a significant role in cellular motility and morphology. It is a part of the Arp2\/3 complex which consists of seven subunits that assemble to promote actin nucleation. This complex is central to the formation of branched actin networks which are necessary for processes such as cell movement endocytosis and vesicle trafficking. Through its mechanical action within the Arp2\/3 complex Arp3 influences the dynamic rearrangement of the cytoskeleton necessary for cellular responses to external stimuli.\u003cbr\u003e\nPathways\u003cbr\u003e\nArp3 functions within the Wiskott-Aldrich syndrome protein (WASP) pathway and the Rho family of GTPases pathway. These pathways are important for regulating the actin cytoskeleton dynamics. The WASP pathway activates Arp2\/3 complex triggering branched actin filament assembly. This process interacts with proteins like Cdc42 a member of the Rho GTPase family which further modulates cytoskeletal organization. Through these interactions Arp3 assists in coordinating actin-based processes critical to cell shape and movement.\u003cbr\u003e\nArp3 links to immune system problems and cancer progression. Mutations or dysregulation of the Arp2\/3 complex including Arp3 can lead to immune deficiencies where cellular movement is impaired such as seen in Wiskott-Aldrich Syndrome. Furthermore aberrant Arp3 activity associates with cancer metastasis where altered cell motility plays a role in tumor spread. Connected proteins such as N-WASP often display interaction within these pathological contexts reinforcing Arp3's relevance in disease mechanisms.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850331738281,"sku":"ab151729","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab151729","provider":"Iright","version":"1.0","type":"link"}