{"product_id":"abcam-ab152364","title":"Abcam, ab152364, Recombinant Human EMP2 protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human EMP2 protein is a Human Full Length protein, in the 1 to 167 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:WB, ELISA, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:P54851,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe protein epithelial membrane protein 2 (EMP2) also known as EMP2 or emp002 has a mass of approximately 20 kDa. EMP2 is expressed mainly in epithelial cells and certain tissues including the lungs breast and reproductive tissues. It appears on the cell surface where it modulates several cell processes. EMP2 plays a role in cell surface configuration by influencing the localization of other critical membrane proteins.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nEMP2 influences the cell's ability to undergo endocytosis a process important for nutrient uptake and signal transduction. It is part of a multiprotein complex that interacts with integrin and caveolin which are essential for cellular adhesion and signaling. EMP2 impacts cellular communication and growth emphasizing its role in maintaining cellular homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nEMP2 is involved in the integrin-mediated pathway and the caveolae-mediated endocytosis pathway. It impacts integrin beta-1 (ITGB1) and c-Src kinase which are proteins important in cell signaling and mobility. These pathways facilitate various cellular functions including signal transmission and regulation of the cytoskeleton. EMP2's interaction with these pathways underlines its significance in cellular processes.\u003cbr\u003e\nEMP2 has connections to lung cancer and endometriosis. Its altered expression influences disease progression and is associated with metastatic potential. EMP2 acts in concert with proteins such as β-catenin and fibronectin which contribute to cancer development and cellular invasiveness. Understanding EMP2's role offers insights into potential therapeutic targets for these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843893678249,"sku":"ab152364","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab152364","provider":"Iright","version":"1.0","type":"link"}