{"product_id":"abcam-ab153607","title":"Abcam, ab153607, Recombinant Human GPCR TGR5 protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human GPCR TGR5 protein is a Human Full Length protein, in the 1 to 330 aa range, expressed in Wheat germ, suitable for ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q8TDU6,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGPCR TGR5 also known as G protein-coupled bile acid receptor 1 (GPBAR1) is a member of the GPCR superfamily. This receptor weighs approximately 35 kDa and is expressed in various tissues including liver intestine brown adipose tissue and macrophages. It functions as a membrane receptor that binds bile acids which activates downstream signaling pathways influencing metabolic processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGPCR TGR5 plays a role in energy metabolism and the immune response. It does not form part of a larger receptor complex but interacts with different proteins to mediate its effects. Upon activation by bile acids TGR5 stimulates the production of cyclic AMP (cAMP) and regulates the release of various cytokines influencing metabolic rate and promoting anti-inflammatory effects.\u003cbr\u003e\nPathways\u003cbr\u003e\nGPCR TGR5 links to the cAMP signaling pathway and plays a role in the brown adipose tissue activation pathway. It is closely related to proteins like adenylate cyclase which it activates to increase cAMP levels and potentially interacts with nuclear receptors modifying gene expression linked to energy homeostasis and inflammation control.\u003cbr\u003e\nGPCR TGR5 associates with metabolic disorders such as obesity and type 2 diabetes. Its role in regulating energy expenditure makes it a target for combating obesity where it influences pathways involving protein partners like adenylate cyclase. Additionally its involvement in controlling inflammation connects it to diseases involving immune dysregulation offering potential pathways for therapeutic interventions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843926708393,"sku":"ab153607","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab153607","provider":"Iright","version":"1.0","type":"link"}