{"product_id":"abcam-ab153835","title":"Abcam, ab153835, Anti-THEA antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal THEA antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ACOT11 aa 1-250.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human ACOT11 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.Q8WXI4\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTHEA also known as Threonine E1A or THREA1 is an important protein involved in cellular processes. This target has a molecular mass of approximately 42 kDa. THEA is expressed in various tissues with high levels found particularly in the brain and liver. Through its mechanical role THEA contributes to cellular metabolism and signaling by participating in enzymatic reactions critical for cell function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTHEA influences several aspects of cell growth and maintenance. It operates as part of an enzymatic complex that facilitates the phosphorylation of substrate molecules essential for many signaling pathways. This activity supports cellular energy regulation and can affect the cell cycle and synaptic function. Its impact on cellular metabolism highlights its importance in tissue homeostasis indicating a wide range of biological influences.\u003cbr\u003e\nPathways\u003cbr\u003e\nTHEA plays a significant role in metabolic and signaling pathways. It interacts closely with the AMPK signaling pathway which is critical for energy balance and homeostasis. In these processes THEA can influence related proteins such as LKB1 and PKA which further propagate signals to activate downstream pathways that maintain energy homeostasis and cellular response to metabolic stress.\u003cbr\u003e\nTHEA's activity links to metabolic syndromes and neurodegenerative diseases. Its altered function can contribute to conditions like diabetes where metabolic pathways become dysregulated. It also associates with Alzheimer's disease with stress on the AMPK pathway. In these diseases interactions with proteins like Tau and GSK3β can modulate disease progression highlighting the diverse roles of THEA in pathological states.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854089113769,"sku":"ab153835","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab153835","provider":"Iright","version":"1.0","type":"link"}