{"product_id":"abcam-ab154612","title":"Abcam, ab154612, Anti-TUBA8 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal TUBA8 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TUBA8 aa 1-300.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:ICC\/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human TUBA8 aa 1-300. The exact immunogen used to generate this antibody is proprietary information.Q9NY65\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTUBA8 also known as tubulin alpha 8 is a protein involved in maintaining the structure of microtubules. It has a molecular mass of about 50 kDa. This protein serves as an important component of the cytoskeleton helping in cellular shape and intracellular transport. Expression of TUBA8 occurs in various tissues including brain and testes but it is not restricted to these. TUBA8 forms heterodimers with beta-tubulin to construct microtubules playing an essential mechanical role in cell stability and movement.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTUBA8 contributes to important cellular processes including cell division movement and intracellular transport. It forms part of the microtubule network essential for the dynamic functions of the cytoskeleton. The protein interacts with other tubulin isoforms and various associated proteins facilitating proper cellular function and structure maintenance. By guiding vesicle transport TUBA8 further influences cell signaling and organization.\u003cbr\u003e\nPathways\u003cbr\u003e\nTUBA8 plays an important role in the microtubule assembly pathway and interacts with the mitogen-activated protein kinase (MAPK) pathway. TUBA8's proper functioning is necessary for cellular activities such as mitosis where microtubule dynamics are critical. In the MAPK pathway TUBA8 coordinates with proteins like MAPK1 and MAPK3 impacting cell survival and apoptosis. These interactions show TUBA8's importance in cellular response systems.\u003cbr\u003e\nAbnormalities in TUBA8 are linked to complex disorders such as lissencephaly and microcephaly. These conditions involve disrupted brain development and abnormal nerve cell positioning highlighting TUBA8's role in neural development. Additionally changes in TUBA8 expression relate to disorders involving the protein LIS1 which also affects microtubule dynamics and brain development. Understanding TUBA8's contribution to these disorders aids in identifying potential therapeutic targets.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854183813289,"sku":"ab154612","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab154612","provider":"Iright","version":"1.0","type":"link"}