{"product_id":"abcam-ab154810","title":"Abcam, ab154810, Anti-ETV3 antibody [EPR8658]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal ETV3 antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Human, Mouse, Rat samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR8658,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nETV3 also known as ETS Variant 3 functions as a transcriptional repressor. The protein has a mass of approximately 61 kDa. It is expressed in multiple tissues including skin liver and immune cells. The presence of ETV3 is important for regulating gene expression as it can bind to specific DNA sequences and inhibit transcription of target genes. This ability allows ETV3 to maintain control over cellular processes such as proliferation and differentiation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe functionality of ETV3 extends to modulation of immune responses and cellular development. ETV3 along with other transcription factors forms parts of multi-protein complexes. Its role in these complexes involves the repression of gene activity directly influencing cell cycle progression and immune system activity. ETV3’s expression and interactions suggest it coordinates with other molecules to maintain homeostasis and appropriate cellular functions.\u003cbr\u003e\nPathways\u003cbr\u003e\nETV3 integrates into two main biological pathways: the MAPK signaling pathway and immune response regulation. Within the MAPK pathway ETV3 interacts with proteins such as ERK influencing cell survival and differentiation outcomes. Meanwhile it connects in immune pathways by modulating activity of other transcription factors impacting immune cell behaviors and responses.\u003cbr\u003e\nETV3 plays a role in conditions like skin cancer and immune system diseases. Aberrant expression or mutation of ETV3 correlates with melanoma development where disrupted regulation contributes to abnormal cell proliferation. Its interactions with proteins such as MITF are particularly relevant in melanoma. Additionally ETV3's role in immune modulation can influence autoimmune disorders where dysregulation leads to improper immune activation or repression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850441445545,"sku":"ab154810","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab154810","provider":"Iright","version":"1.0","type":"link"}