{"product_id":"abcam-ab154841","title":"Abcam, ab154841, Anti-GUCY1B3 antibody [EPR8822]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal GUCY1B3 antibody. Suitable for IHC-P, WB and reacts with Human, Mouse, Rat samples. Cited in 14 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR8822,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:The mouse and rat recommendation is based on the WB results. We do not guarantee IHC-P for mouse and rat.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGUCY1B3 also known as guanylate cyclase soluble subunit beta-1 serves as a subunit of the soluble guanylate cyclase (sGC) complex. This protein acts in converting GTP to cGMP which plays an important role in intracellular signaling. GUCY1B3 has a molecular mass of approximately 70 kDa. The expression of GUCY1B3 occurs in a variety of tissues with higher levels observed in smooth muscle cells and neurons.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe GUCY1B3 protein functions as part of the soluble guanylate cyclase complex which directly responds to nitric oxide (NO) signaling. This NO binding leads to the production of cyclic GMP a secondary messenger involved in numerous biological responses. These responses include vasodilation and neurotransmission. GUCY1B3's activity regulates essential cellular processes through these mechanisms.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe sGC complex involving GUCY1B3 participates in the nitric oxide signaling pathway which is significant for cardiovascular function. Additionally GUCY1B3 works alongside GUCY1A3 another subunit of the sGC complex to facilitate this signaling cascade. The resulting cGMP acts in downstream pathways like the cGMP-dependent protein kinase G (PKG) pathway which controls vascular tone and cardiac function.\u003cbr\u003e\nGUCY1B3 plays a role in complications such as hypertension and pulmonary hypertension. Disruption in NO signaling involving GUCY1B3 can result in impaired vasodilation contributing to these conditions. Moreover alterations in the function of GUCY1A3 the partner in the sGC complex can affect the same pathways further implicating GUCY1B3 in the pathology of cardiovascular disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844180136105,"sku":"ab154841","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab154841","provider":"Iright","version":"1.0","type":"link"}