{"product_id":"abcam-ab154855","title":"Abcam, ab154855, Anti-VAX2 antibody [EPR10424]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal VAX2 antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR10424,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:The alignment of the immunogen sequence of ab154855 and human and rat VAX1 shows a high homology of 92% (human) and 93% (rat). Based on the sequence, a cross-reaction of ab154855 with VAX1 is very likely, although this has not been experimentally tested by us.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse: We have preliminary internal testing data to indicate this antibody may not react with this species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nVAX2 also known as Ventral Anterior Homeobox 2 is a transcription factor with a significant role in embryonic development. It has a molecular mass of around 36 kDa. VAX2 is primarily expressed in the developing central nervous system including the brain and eyes. This protein belongs to the homeobox gene family which regulates patterns of anatomical development.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nVAX2 controls the expression of genes involved in eye development. It is part of a transcriptional complex that includes proteins like VAX1 and PAX6. Together these proteins coordinate the formation of structures within the eye such as the retina. VAX2 ensures the correct spatial patterning and differentiation of photoreceptor cells maintaining proper eye morphogenesis.\u003cbr\u003e\nPathways\u003cbr\u003e\nVAX2 plays a role in the retinal morphogenesis pathway and interacts closely with the Hedgehog signaling pathway. It works in tandem with proteins such as Sonic Hedgehog (SHH) to influence cellular differentiation and positional identity during development. VAX2's expression is regulated by these pathways demonstrating its integral function in developmental processes.\u003cbr\u003e\nVAX2 has connections to eye disorders like coloboma and microphthalmia. These conditions are linked to mutations or dysregulations in genes that work alongside VAX2 such as PAX6. Any disruptions in VAX2 expression or function can lead to improper eye development potentially resulting in visual impairment or blindness. VAX2’s role highlights its significance in maintaining normal developmental processes and preventing congenital disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850406187177,"sku":"ab154855","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab154855","provider":"Iright","version":"1.0","type":"link"}