{"product_id":"abcam-ab154939","title":"Abcam, ab154939, Anti-Proteasome 26S S3\/PSMD3 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal Proteasome 26S S3\/PSMD3 antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PSMD3 aa 300 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human PSMD3 aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O43242\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nKeep as concentrated solution.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Proteasome 26S S3 also known as PSMD3 is an essential component of the 26S proteasome complex which plays a critical role in degrading ubiquitinated proteins. It has a molecular mass of approximately 61 kDa and is important in maintaining protein homeostasis by regulating protein degradation. The 26S proteasome is expressed ubiquitously in eukaryotic cells indicating its importance in various cellular processes. Its activity ensures the removal of damaged or misfolded proteins which is necessary for proper cellular function and survival.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nProteasome 26S S3 forms an integral part of the 26S proteasome a large complex involved in the ATP-dependent breakdown of proteins. This complex is essential for many cellular functions including cell cycle progression signal transduction and stress responses. By facilitating protein degradation Proteasome 26S S3 helps regulate the quantity and quality of proteins within the cell. It interacts with other proteasomal components to mediate the recognition and unfolding of target proteins enabling their subsequent degradation into smaller peptides.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe Proteasome 26S S3 participates in the ubiquitin-proteasome pathway and the NF-κB signaling pathway. These pathways are pivotal in controlling protein turnover and are involved in cellular responses to various stimuli. Within the ubiquitin-proteasome pathway PSMD3 collaborates with other proteasome components to execute protein degradation processes. In the NF-κB pathway PSMD3 influences the degradation of IκB proteins allowing the activation of NF-κB transcription factors which regulate immune and inflammatory responses.\u003cbr\u003e\nDysregulation of Proteasome 26S S3 activity has links to cancer and neurodegenerative diseases. Abnormal proteasome function can result in the accumulation of damaged proteins contributing to the pathogenesis of these conditions. In cancer alterations in the proteasome function can lead to uncontrolled cell growth and survival where PSMD3 interacts with proteins like p53 and Bcl-2 affecting apoptosis and cell cycle regulation. In neurodegenerative diseases compromised proteasome activity may lead to the accumulation of misfolded proteins exacerbating conditions such as Alzheimer's or Parkinson's disease.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854143672489,"sku":"ab154939","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab154939","provider":"Iright","version":"1.0","type":"link"}