{"product_id":"abcam-ab156002","title":"Abcam, ab156002, Anti-Rapsyn antibody [EPR9759]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal Rapsyn antibody. Suitable for WB and reacts with Rat, Mouse samples. Cited in 10 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR9759,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRapsyn also known as receptor-associated protein of the synapse or 43 kDa postsynaptic protein has a mass of 43 kilodaltons. Rapsyn is mainly expressed in skeletal muscle tissues. Mechanically it plays a role as a scaffolding protein that links nicotinic acetylcholine receptors (nAChRs) to the postsynaptic cytoskeleton at neuromuscular junctions. This association ensures proper clustering of nAChRs which is essential for efficient synaptic transmission.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRapsyn facilitates the organization and stabilization of acetylcholine receptors at the neuromuscular junction. It acts as part of a larger protein complex that anchors these receptors to the skeletal muscle surface. Macromolecular complexes like those involving Rapsyn are important for the formation and maintenance of the postsynaptic membrane which ensures effective muscle contraction in response to nerve signals. Additionally Rapsyn assists in the aggregation of receptors during synaptogenesis the process by which synapses form between neurons and muscle fibers.\u003cbr\u003e\nPathways\u003cbr\u003e\nRapsyn contributes to signal transduction and synaptic transmission processes. It associates closely with Dystrophin-glycoprotein complex (DGC) pathway maintaining the structural integrity of the neuromuscular junction. Rapsyn interacts with proteins such as MuSK (Muscle-Specific Kinase) to facilitate nAChR clustering during synapse formation. This interaction also involves agrin-mediated signaling which is critical in neuromuscular development and function.\u003cbr\u003e\nMutations or dysfunctions in Rapsyn can be linked to conditions such as congenital myasthenic syndromes (CMS). CMS involves impaired neuromuscular transmission causing muscle weakness and fatigue. Rapsyn mutations can disrupt its interaction with proteins like nAChRs and MuSK compromising synaptic stability and efficiency. Another related disorder is limb-girdle muscular dystrophy where pathways involving Rapsyn and DGC proteins are affected leading to progressive muscle weakness and degeneration.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850306113705,"sku":"ab156002","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab156002","provider":"Iright","version":"1.0","type":"link"}