{"product_id":"abcam-ab156013","title":"Abcam, ab156013, Anti-FGFR1 Oncogene Partner antibody [EPR9929]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal FGFR1 Oncogene Partner antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR9929,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe FGFR1 Oncogene Partner also known as FOP is a protein predominantly involved in cellular processes related to the fibroblast growth factor receptor 1 (FGFR1). It exhibits a molecular weight of approximately 60 kDa. FGFR1 Oncogene Partner is expressed in various tissues including bone marrow and other hematopoietic tissues. It contains conserved regions essential for its function as a molecular adaptor or scaffold playing a significant role in protein-protein interactions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nFOP functions as an adaptor protein facilitating the assembly and organization of the centrosome a critical cellular structure required for proper cell division. FOP plays a role in the formation of a multi-protein complex comprising FGFR1 contributing to cellular signaling regulation. This complex assists in ensuring appropriate cellular responses to growth factor stimuli. FOP displays interactions with other cytoskeletal and signaling proteins highlighting its importance in modulating cellular architecture and division.\u003cbr\u003e\nPathways\u003cbr\u003e\nVarious proteins interact with FGFR1 Oncogene Partner as part of the FGFR signaling and centrosome architecture processes. The primary pathway involving FOP is the FGFR signaling pathway where it facilitates the FGFR1's recruitment to the centrosome. This interaction allows for efficient signal transduction necessary for cell proliferation and differentiation. FOP also associates with proteins like ALMS1 affecting cellular organization and stability highlighting its participation in centrosome-related signaling cascades.\u003cbr\u003e\nAlterations in FOP expression or function have links to various conditions notably cancer and craniosynostosis. In certain cancers FOP involvement with FGFR1 leads to oncogenic fusion proteins enhancing aberrant signaling and contributing to tumor growth and progression. Furthermore craniosynostosis links to disruptions in centrosome functionality where mutated FOP can affect skeletal development. The protein's interactions with FGFR1 and other centrosomal partners position it significantly in the etiology of these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850406613161,"sku":"ab156013","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab156013","provider":"Iright","version":"1.0","type":"link"}