{"product_id":"abcam-ab156017","title":"Abcam, ab156017, Anti-Syntaxin 18 antibody [EPR8939]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal Syntaxin 18 antibody. Suitable for IHC-P, WB and reacts with Mouse, Human, Rat samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR8939,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSyntaxin 18 also known as STX18 is a membrane protein that plays an important role in intracellular protein transport. This protein has an approximate molecular mass of 34.5 kDa and primarily resides in the endoplasmic reticulum (ER). Syntaxin 18 helps mediate vesicle trafficking facilitating the movement of different molecules between the ER and the Golgi apparatus. It acts as a target-specific SNARE protein which stands for \"soluble N-ethylmaleimide-sensitive factor attachment protein receptor.\" SNARE proteins are known for their role in fusion processes of transport vesicles to their target membranes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSyntaxin 18 is involved in maintaining cellular homeostasis. It functions as part of a larger complex often referred to as the Syntaxin 18 complex which also includes other proteins such as SNARE partners Use1 BNIP1 and Sec22b. This protein complex is essential in the post-translational transport of proteins from the ER to the Golgi. Syntaxin 18 ensures precise vesicle targeting and fusion which is important for proper cell function and protein maturation processes within the secretory pathway.\u003cbr\u003e\nPathways\u003cbr\u003e\nSyntaxin 18 integrates into the secretory pathway where it coordinates with other proteins like VAMP7 and SNAP29 to facilitate vesicle transport. This pathway is vital for the regulation of protein and lipid shipping within cells. Syntaxin 18 also plays an integral role in the ER-to-Golgi transport vesicles which are important in protein secretion and autophagy. As Syntaxin 18 is linked to proteins involved in vesicular trafficking it is critical in ensuring that cellular components are distributed efficiently within the cell.\u003cbr\u003e\nSyntaxin 18 has associations with neurodegenerative disorders such as Alzheimer's disease due to its role in protein traffic dysregulation. Abnormal expression or mutations in Syntaxin 18 can disrupt vesicular transport leading to cellular stress and pathological aggregates that relate to these diseases. Furthermore Syntaxin 18 interacts with proteins like VAMP7 which also impacts processes implicated in certain autoimmune diseases. Understanding these interactions provides insights into how impaired Syntaxin 18 function contributes to disease progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850354348201,"sku":"ab156017","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab156017","provider":"Iright","version":"1.0","type":"link"}