{"product_id":"abcam-ab156727","title":"Abcam, ab156727, Recombinant Human LAGE3 protein","description":"\u003cp\u003eSize: 20µg\u003cbr\u003e\nRecombinant Human LAGE3 protein is a Human Full Length protein, in the 1 to 143 aa range, expressed in Escherichia coli, with \u0026gt;85%, suitable for SDS-PAGE, Mass Spec.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;85% SDS-PAGE,\u003cbr\u003e\nExpression system:Escherichia coli,\u003cbr\u003e\nTags:His tag N-Terminus,\u003cbr\u003e\nApplications:SDS-PAGE, Mass SpecSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q14657,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.03% (R*,R*)-1,4-Dimercaptobutan-2,3-diol\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nLAGE3 also known as CTAG2 is a member of the human cancer\/testis antigen family. This protein has an approximate mass of 16 kDa. It shows expression in various tissues but is notably present in testis tissue. LAGE3 is an important part of cellular processes where it takes part in the functionality of tRNAs affecting protein translation within the cell.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nLAGE3 fits into the tRNA modification complex where it enhances the modification of tRNA molecules. This role is important for maintaining correct protein synthesis as it ensures proper codon recognition and translation fidelity. LAGE3 pairs with other proteins to form a functional complex that effectively influences translational precision during protein production.\u003cbr\u003e\nPathways\u003cbr\u003e\nLAGE3 actively contributes to the tRNA modification pathway and is linked with the protein translation process. Its association with the KEOPS\/EKC complex indicates interactions with proteins like OSGEP and TP53RK both involved in maintaining cellular translational processes. These connections illustrate its importance in ensuring accurate protein assembly.\u003cbr\u003e\nLAGE3 is linked to cancer and autoimmune disorders. Its expression profiles relate to cancer where LAGE3 might act as a potential biomarker for testicular cancer. In autoimmune disorders its interaction with proteins such as CTAG1B plays a role in immune response regulation. These associations suggest LAGE3's potential impact on pathogenic processes and therapeutic opportunities in oncology and immune-related conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844018950313,"sku":"ab156727","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab156727","provider":"Iright","version":"1.0","type":"link"}