{"product_id":"abcam-ab157209","title":"Abcam, ab157209, Anti-GPCR GPR1 antibody [EPR11008]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal GPCR GPR1 antibody. Suitable for WB and reacts with Rat, Human samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR11008,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Rat, Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse: We have preliminary internal testing data to indicate this antibody may not react with this species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGPR1 a G protein-coupled receptor (GPCR) is an integral membrane protein that plays a role in cellular signaling. Known alternatively as G protein-coupled receptor 1 its mass is about 41 kDa. GPR1 localizes in the cell membrane primarily expressed in tissues like the brain and kidney. Its function involves interaction with specific ligands leading to the activation of G-proteins and the downstream signaling cascade. This makes it an important player in transmitting extracellular signals to the interior of the cell.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGPR1 takes part in inflammatory response and metabolism regulation. It does not appear to form part of a larger protein complex functioning independently in the pathways it influences. GPR1's role in attracting immune cells to sites of inflammation is significant as it interacts with chemokines to mediate leucocyte migration. In cellular metabolism GPR1 helps maintain energy balance by modulating pathways linked to energy and nutrient availability.\u003cbr\u003e\nPathways\u003cbr\u003e\nGPR1 interacts with the MAPK signaling pathway and the chemokine-mediated signal transduction. These pathways involve proteins like ERK1\/2 and CCR1 which help transmit signals that affect cellular responses such as growth differentiation or immune cell trafficking. GPR1 influences these pathways through ligand-binding leading to a cascade of intracellular events that impact cell function and communication.\u003cbr\u003e\nGPR1 is associated with inflammation-related diseases and metabolic disorders. For instance its role in inflammation pathways links it to conditions like rheumatoid arthritis. It may also contribute to obesity by affecting energy regulation pathways. The protein demonstrates interaction with other receptors like CCR5 in these diseases which facilitates a better understanding of its involvement in pathological states. Researchers are exploring GPR1 as a potential therapeutic target given its role in these disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850362441897,"sku":"ab157209","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab157209","provider":"Iright","version":"1.0","type":"link"}