{"product_id":"abcam-ab158422","title":"Abcam, ab158422, Recombinant Human MS4A2 protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human MS4A2 protein is a Human Full Length protein, in the 1 to 244 aa range, expressed in Wheat germ, suitable for ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q01362,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMS4A2 also known as FcεRIβ or High-affinity IgE receptor beta subunit weighs approximately 30 kDa. This protein is expressed mostly in mast cells and basophils. MS4A2 functions as part of the high-affinity IgE receptor complex which is critical in mediating immune responses that are rapid and strong. In terms of structure the MS4A family consists of proteins with four transmembrane domains including MS4A2 playing a role in signal transduction processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMS4A2 contributes significantly to the immune system by participating in allergic response signaling. It assembles with other subunits — alpha and gamma — to form the tetrameric IgE receptor complex. This complex on mast cells and basophils detects IgE antibodies bound to allergens triggering the release of inflammatory mediators like histamine. These mediators lead to symptoms associated with allergic reactions such as asthma and anaphylaxis. MS4A2's interaction with allergens through the receptor complex makes it an essential player in immune surveillance and response.\u003cbr\u003e\nPathways\u003cbr\u003e\nMS4A2 directly influences the Fc epsilon RI signaling pathway an essential component in immune responses especially related to allergy and hypersensitivity reactions. The pathway not only involves MS4A2 but also proteins like Lyn and Syk kinase which further relay the signals initiated by antigen-IgE binding. This interaction can lead to robust downstream immune responses including inflammatory processes. The MS4A2 protein's role in this pathway connects it with other signaling cascades enhancing cell activation and response.\u003cbr\u003e\nResearch identifies MS4A2's relevance in allergic asthma and atopic dermatitis. These conditions often involve an overactive immune response to environmental allergens where MS4A2 plays a central role. In these diseases the interaction of MS4A2 with other molecules such as IL-4 and IL-13 reveals its influence on disease pathology. This understanding helps in considering potential therapeutic targets as MS4A2's contribution to disease progression offers a path to developing treatments focused on modulating allergic response pathways.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843916189865,"sku":"ab158422","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab158422","provider":"Iright","version":"1.0","type":"link"}