{"product_id":"abcam-ab159130","title":"Abcam, ab159130, Recombinant Human PI 3 Kinase p85 (SH2) protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human PI 3 Kinase p85 (SH2) protein is a Human Full Length protein, in the 1 to 454 aa range, expressed in Wheat germ, suitable for ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:P27986,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPI 3 Kinase p85 also known as the regulatory subunit of phosphoinositide 3-kinase forms part of the PI3K complex which plays an important role in cellular functions. The p85 subunit with an approximate molecular mass of 85 kDa binds to and regulates the catalytic p110 subunit. This binding is necessary for the activation of the PI3K enzyme complex. PI 3 Kinase p85 is widely expressed across a variety of tissues particularly abundant in immune cells where it contributes to signaling pathways that regulate cell growth and survival.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPI 3 Kinase p85 acts to stabilize the catalytic subunit allowing for proper signal transduction in response to external stimuli. As part of the PI3K complex it is essential for the regulation of the enzyme's substrate specificity and activity. This complex facilitates the conversion of PIP2 to PIP3 a lipid second messenger that is important in various signalling pathways. Through its actions PI 3 Kinase p85 supports cell proliferation differentiation and metabolism impacting numerous cellular processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nPI 3 Kinase p85 plays significant roles within the PI3K\/AKT and mTOR signaling pathways. These pathways are fundamental to regulating processes like cell metabolism apoptosis and protein synthesis. In the PI3K\/AKT pathway the p85 subunit collaborates closely with the catalytic p110 subunit to phosphorylate and activate AKT an important downstream effector. In the mTOR pathway it influences cellular response to growth factors. These interactions of PI 3 Kinase p85 with other proteins display its centrality to critical cellular activities.\u003cbr\u003e\nPI 3 Kinase p85 has a significant association with cancer and insulin resistance. Over-activation of PI3K signaling often results in oncogenesis where the deregulation of cell growth and division occurs. Aberrant activity of PI 3 Kinase p85 particularly alterations in its regulatory role is linked to tumorigenesis via interactions with AKT protein in the cancer context. In insulin resistance defective signaling reduces the effectiveness of insulin-mediated glucose uptake. The connection of PI 3 Kinase p85 with these proteins and disorders highlights its importance in pathological conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843966128297,"sku":"ab159130","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab159130","provider":"Iright","version":"1.0","type":"link"}