{"product_id":"abcam-ab161234","title":"Abcam, ab161234, Recombinant Human FATP3 protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human FATP3 protein is a Human Fragment protein, in the 635 to 730 aa range, expressed in Wheat germ, suitable for ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q5K4L6,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe FATP3 protein also called SLC27A3 functions as an acyl-CoA synthetase involved in the uptake and activation of long-chain fatty acids. It has a molecular mass of approximately 79 kDa. FATP3 is primarily expressed in tissues such as the heart liver and adipose tissues suggesting its role in energy metabolism. Its function involves the import and subsequent esterification of fatty acids an essential step in lipid metabolism.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nFATP3 plays an important role in energy homeostasis by facilitating fatty acid transport and activation. It operates as part of a multiprotein complex localized to the mitochondria-associated endoplasmic reticulum membrane. This complex supports the synthesis and turnover of cellular lipids by integrating fatty acids into pathways for triglyceride and phospholipid synthesis highlighting its role in managing cellular lipid stores and membrane composition.\u003cbr\u003e\nPathways\u003cbr\u003e\nFATP3 mediates coordination between lipid transport and metabolism within fatty acid oxidation and biosynthesis pathways. Key pathways include the beta-oxidation pathway where fatty acids are degraded to produce energy and the phospholipid biosynthesis pathway important for membrane formation. FATP3 interacts with proteins such as acyl-CoA dehydrogenase and diacylglycerol acyltransferase aiding in lipid synthesis and metabolism.\u003cbr\u003e\nFATP3 has been linked to conditions such as metabolic syndrome and type 2 diabetes where fatty acid metabolism is disrupted. The protein interacts with enzymes like lipoprotein lipase which regulates lipid levels. Abnormal FATP3 activity could lead to altered cholesterol and triglyceride levels contributing to the pathogenesis of these metabolic disorders. Understanding FATP3’s function may provide insight into therapeutic targets for managing such diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843943518377,"sku":"ab161234","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab161234","provider":"Iright","version":"1.0","type":"link"}