{"product_id":"abcam-ab161722","title":"Abcam, ab161722, Recombinant Human Cbl-c protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human Cbl-c protein is a Human Full Length protein, in the 1 to 474 aa range, expressed in Wheat germ, suitable for ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q9ULV8,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCbl-c also known as Casitas B-lineage lymphoma protein C is a member of the Cbl family of ubiquitin ligases. This protein has an approximate mass of 56 kDa and is expressed in various tissues including skeletal muscle and the uterus. Cbl-c functions as an E3 ubiquitin-protein ligase which means it tags target proteins for degradation by the proteasome. By doing so it regulates protein turnover and maintains cellular protein balance.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCbl-c interacts with signaling complexes and modulates signal transduction pathways. It participates in processes such as negative regulation of tyrosine kinase signaling. Cbl-c operates alongside other proteins in the Cbl family including Cbl and Cbl-b to downregulate signaling through ubiquitination. It plays a significant role in the regulation of cellular growth and differentiation by targeting specific proteins for degradation.\u003cbr\u003e\nPathways\u003cbr\u003e\nCbl-c interacts with cellular signaling mechanisms involved in the regulation of growth and cellular response. Cbl-c is an important component of pathways like the Epidermal Growth Factor Receptor (EGFR) signaling pathway and the Insulin signaling pathway. Through these pathways Cbl-c also interacts with receptor tyrosine kinases such as EGFR and insulin receptors impacting cellular processes like proliferation migration and apoptosis.\u003cbr\u003e\nMutations or dysregulation of Cbl-c have associations with tumor progression and metabolic disorders. Cancer and insulin resistance are two conditions in which alterations in Cbl-c function contribute to disease pathology. Interactions with proteins such as EGFR and insulin receptor through these disorders highlight Cbl-c’s involvement in critical regulatory networks impacting human health.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843951546537,"sku":"ab161722","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab161722","provider":"Iright","version":"1.0","type":"link"}