{"product_id":"abcam-ab162373","title":"Abcam, ab162373, Recombinant Human SPOCK3 protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human SPOCK3 protein is a Human Fragment protein, in the 132 to 230 aa range, expressed in Wheat germ, suitable for ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q9BQ16,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSPOCK3 also known as Testican-3 is part of the SPARC family of proteins. Testican-3 has a molecular mass of approximately 50 kDa. This protein is primarily expressed in the central nervous system particularly in the brain and is also found in cartilage. It contains calcium-binding domains which suggest its involvement in cellular interactions and signaling processes. Testican-3 is mainly located in the extracellular matrix where it interacts with other matrix proteins and modulates their functions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTestican-3 plays a role in processes involving the structural integrity and remodeling of tissues. It belongs to the testican family which contributes to the regulation of matrix metalloproteinases (MMPs) and other proteins that participate in the degradation of the extracellular matrix. Testican-3's interactions help in maintaining matrix homeostasis by controlling protease activity which is critical for maintaining tissue structure and function.\u003cbr\u003e\nPathways\u003cbr\u003e\nTestican-3's interactions influence the cell-extracellular matrix communication and signaling pathways. These pathways include the regulation of matrix metalloproteinases which are important for tissue remodeling and repair. Testican-3 is involved with proteins such as MMPs and other extracellular matrix components helping coordinate protease activity and influencing cellular behavior in response to environmental changes.\u003cbr\u003e\nTestican-3's expression and regulation are linked to cancer and neurological disorders. Its influence on matrix metalloproteinases associates it with cancer by affecting tumor growth and metastasis due to its role in the matrix degradation pathway. In neurological contexts abnormalities in Testican-3 activity could impact processes such as synaptogenesis or neuroinflammation connecting it to conditions where matrix changes are relevant.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843962032297,"sku":"ab162373","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab162373","provider":"Iright","version":"1.0","type":"link"}