{"product_id":"abcam-ab162810","title":"Abcam, ab162810, Recombinant Human RSBN1\/Rosbin protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human RSBN1\/Rosbin protein is a Human Full Length protein, in the 1 to 411 aa range, expressed in Wheat germ, suitable for ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q5VWQ0,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product was previously labelled as RSBN1.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRSBN1 also known as Rosbin encodes a protein involved in regulating structures within the cell nucleus. RSBN1 has a mass of approximately 94 kDa and is predominantly expressed in tissues with rapidly dividing cells such as the testis and certain cancerous tissues. This protein localizes mainly in the nucleoplasm indicating its role in nuclear processes. Its function and localization suggest it as a potential player in maintaining nuclear architecture and chromatin organization.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe protein encoded by RSBN1 participates in chromatin remodeling which is essential for gene expression regulation and DNA replication. It acts as part of a larger chromatin-associated complex where it supports the structural changes needed for efficient transcription and replication processes. By modulating chromatin accessibility RSBN1 influences cell cycle progression affecting cell proliferation.\u003cbr\u003e\nPathways\u003cbr\u003e\nRSBN1 plays a role in the chromatin organization pathway and cell cycle regulation. It interacts with histone modification enzymes facilitating the deposition of histone marks that modify chromatin structure. RSBN1 is associated with proteins like ATRX that have roles in chromatin remodeling and telomere maintenance contributing to genomic stability during cell division.\u003cbr\u003e\nRSBN1 has shown a link to cancer progression particularly in testicular and digestive system cancers. Alterations in RSBN1 expression or function lead to disrupted chromatin organization resulting in uncontrolled cell proliferation a hallmark of cancer. The interaction with ATRX and other chromatin-modifying proteins further connects RSBN1 to these malignancies with potential implications in tumor progression and treatment resistance.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843976220841,"sku":"ab162810","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab162810","provider":"Iright","version":"1.0","type":"link"}