{"product_id":"abcam-ab163332","title":"Abcam, ab163332, Recombinant Human PCDHAC2 protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human PCDHAC2 protein is a Human Full Length protein, in the 1 to 884 aa range, expressed in Wheat germ, suitable for ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q9Y5I4,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPCDHAC2 also known as protocadherin alpha C2 is part of the protocadherin alpha subfamily. This protein has a molecular mass of approximately 105 kDa. It localizes to the cell membrane prominently expressed in neural tissues. PCDHAC2 functions in cell-cell adhesion mediated largely through calcium-binding motifs in its extracellular domain. These interactions contribute to cellular communication and signal transduction essential for the nervous system development.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nProtocadherins like PCDHAC2 play pivotal roles in the neural architecture by mediating homophilic cell adhesion properties. PCDHAC2 does not function as a solitary entity; it forms part of multimeric cadherin complexes at cell junctions. Its ability to mediate specific cell-cell interactions enhances neural circuit organization and synaptic specificity. The precise patterning of these interactions contributes to the establishment of proper brain architecture and connectivity.\u003cbr\u003e\nPathways\u003cbr\u003e\nPCDHAC2 integration involves the calcium-dependent cell adhesion pathway and the Wnt signaling pathway. These pathways are critical for embryonic development and neural differentiation. In these pathways the protein interacts with other cadherins and catenins providing stability and signaling functions. Its actions might regulate cytoskeletal dynamics influencing the neural network's architecture indirectly by modulating the expression of cytoplasmic proteins linked to cellular adhesion and signaling.\u003cbr\u003e\nAberrant PCDHAC2 expression or function connects to neurological disorders such as autism spectrum disorder and schizophrenia. These conditions may involve disruptions in neural connectivity and synaptic function. PCDHAC2-related dysfunctions can affect interactions with proteins like beta-catenin which are significant in signal transduction and synaptic structure. Understanding these associations may provide insights into the molecular pathology underpinning these disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843991752873,"sku":"ab163332","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab163332","provider":"Iright","version":"1.0","type":"link"}