{"product_id":"abcam-ab163525","title":"Abcam, ab163525, Recombinant Human TP73-AS1 protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human TP73-AS1 protein is a Full Length protein, in the 1 to 201 aa range, expressed in Wheat germ, suitable for ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTP73-AS1 also known as tumor protein p73 antisense RNA 1 is a long non-coding RNA involved in gene regulation. The gene does not itself code for a protein so it does not have a molecular mass in the way proteins do. It mainly expresses in tissues such as the brain thyroid and various cancerous tissues. TP73-AS1 regulates gene expression by interacting with other nuclear components modulates chromatin structure and impacts transcriptional activity. The expression of TP73-AS1 plays a role in maintaining cellular homeostasis.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTP73-AS1 functions in regulating cell cycle progression and apoptosis. This RNA does not form a complex by itself but interacts with proteins influencing their activity. By binding to different regulatory proteins TP73-AS1 can modulate the expression of genes involved in cell growth and death processes. Its interactions serve to balance cellular proliferation and programmed cell death which are both critical for normal cellular functioning and organismal health.\u003cbr\u003e\nPathways\u003cbr\u003e\nTP73-AS1 plays roles in several important regulatory networks. It impacts the p53 signaling pathway where it may influence the activity of the p53 protein an important regulator of the cell cycle and apoptosis. TP73-AS1 also interacts with important proteins like MDM2 altering the pathway dynamics that control cell cycle arrest and apoptosis. The proper functioning of these pathways is important for preventing unrestrained cell growth and maintaining genomic stability.\u003cbr\u003e\nTP73-AS1 shows a strong association with various cancers including breast and lung cancer. Dysregulated expression of TP73-AS1 contributes to tumorigenesis and impacts cancer progression by influencing cell growth and survival pathways. TP73-AS1 also impacts diseases associated with the p53 protein where it exacerbates the disordered cell proliferation and resistance to cell death typical of cancerous states. Understanding these interactions offers potential for therapeutic interventions in cancer treatment.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843926151337,"sku":"ab163525","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab163525","provider":"Iright","version":"1.0","type":"link"}