{"product_id":"abcam-ab163740","title":"Abcam, ab163740, Recombinant Human TRAPPC11 protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human TRAPPC11 protein is a Human Full Length protein, in the 1 to 739 aa range, expressed in Wheat germ, suitable for ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q7Z392,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTRAPPC11 also known as Trafficking Protein Particle Complex 11 is a protein with a mass of about 130 kDa. It is found mainly in the Golgi apparatus where it plays an important role in protein trafficking and membrane dynamics. This protein gets expressed in various tissues prominently in cells involved with high levels of secretion and transport. Its function is linked closely to its participation in the trafficking of proteins within the early secretory pathway.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTRAPPC11 is involved in the transport of vesicles from the endoplasmic reticulum to the Golgi. It is a subunit of a larger multisubunit complex called the transport protein particle (TRAPP) complex. As a component of this complex it helps maintain its stability and function ensuring proper trafficking of cargo proteins.\u003cbr\u003e\nPathways\u003cbr\u003e\nVesicle transport TRAPPC11 interacts with critical pathways such as the secretory pathway and endosomal sorting. Within these pathways TRAPPC11 collaborates with other proteins such as TRAPPC2 and TRAPPC3 to maintain vesicle tethering and fusion processes. It contributes significantly to the modulation of transport between the endoplasmic reticulum and Golgi apparatus influencing the efficiency of protein transport and distribution.\u003cbr\u003e\nDisruptions involving TRAPPC11 can lead to abnormal cellular trafficking linked to conditions like congenital muscular dystrophy and intellectual disability. Mutations in this protein have associations with affecting other proteins such as Golgi-related proteins which further highlight its role in cellular organization. Understanding these connections is key in framing TRAPPC11's role in disease pathology providing insights into potential therapeutic approaches.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843951743145,"sku":"ab163740","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab163740","provider":"Iright","version":"1.0","type":"link"}