{"product_id":"abcam-ab164339","title":"Abcam, ab164339, Recombinant Human LMAN2L protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human LMAN2L protein is a Human Full Length protein, in the 1 to 348 aa range, expressed in Wheat germ, suitable for ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q9H0V9,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe LMAN2L protein also known as vesicular integral-membrane protein VIP36-like isoform is approximately 36 kDa in mass. This protein is located mainly in the Golgi apparatus involved in the trafficking of glycoproteins. LMAN2L interacts with N-linked glycoproteins and may function in the secretory pathway. Expression of LMAN2L occurs in various tissues including liver and brain which can suggest its involvement in multiple biological processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nLMAN2L plays a part in glycoprotein transport and sorting within the cell. It acts through participation in the transport of glycosylation-modified proteins contributing to their proper localization and function. The protein is part of a larger group involved in cargo selection and shuttling between organelles. This role is important in ensuring functional protein distribution and maintaining cellular homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nLMAN2L's function integrates with the secretory and glycosylation pathways. It affects protein folding and sorting which are essential for maintaining cellular organization and protein maturation. LMAN2L operates alongside proteins such as ERGIC-53 and other lectin family members facilitating proper glycoprotein trafficking from the ER to the Golgi and through the secretory pathway.\u003cbr\u003e\nMalfunction or misexpression of LMAN2L implicates conditions such as cancer and congenital disorders of glycosylation. LMAN2L in collaboration with calreticulin may contribute to pathologies through disruption in protein trafficking and glycosylation. This protein's dysregulation can influence cell growth and differentiation linking it to tumorigenesis and other developmental anomalies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843925364905,"sku":"ab164339","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab164339","provider":"Iright","version":"1.0","type":"link"}