{"product_id":"abcam-ab165196","title":"Abcam, ab165196, Recombinant Human DEGS2 protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human DEGS2 protein is a Human Full Length protein, in the 1 to 323 aa range, expressed in Wheat germ, suitable for ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q6QHC5,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe DEGS2 protein also known as delta(4)-desaturase sphingolipid 2 plays a mechanical role in lipid metabolism specifically in the desaturation process of sphingolipids. DEGS2 has a molecular mass of around 37 kDa. The protein is expressed in various tissues with notable levels in the liver and skin. Its enzymatic activity converts dihydroceramide to ceramide important steps in the synthesis of sphingolipids molecules essential for cell membrane structure and function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nDEGS2 participates in the biosynthesis of sphingolipids a process important for the maintenance of cellular structure and signaling. It does not form part of a larger enzymatic complex and acts independently in its function. Sphingolipids are involved in important cellular processes such as apoptosis and cell growth which influence cell fate and communication. The role of DEGS2 in sphingolipid metabolism impacts how cells maintain their integrity and react to changes in their environment.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe DEGS2 protein interacts with the sphingolipid metabolic pathway and the apoptosis signaling pathway. It plays a role in the conversion steps of sphingolipid biosynthesis alongside other proteins such as DEGS1 which also participates in the desaturation of dihydroceramide. In apoptosis DEGS2’s production of ceramide acts as a signaling molecule that can influence cell death pathways thereby connecting lipid metabolism with cell survival and death mechanisms.\u003cbr\u003e\nDEGS2 activity relates to sphingolipidoses and skin disorders such as ichthyosis. Abnormal DEGS2 function can lead to disrupted ceramide levels which affects skin barrier integrity and may contribute to the pathology of these conditions. Furthermore this protein’s involvement in sphingolipid metabolism connects it to DEGS1 as changes in the balance and concentrations of sphingolipids can have cascading effects on conditions related to lipid storage and management potentially influencing the progression of metabolic and neurological diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843986837673,"sku":"ab165196","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab165196","provider":"Iright","version":"1.0","type":"link"}