{"product_id":"abcam-ab165536","title":"Abcam, ab165536, Recombinant Human TMED6 protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human TMED6 protein is a Human Full Length protein, in the 1 to 240 aa range, expressed in Wheat germ, suitable for ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q8WW62,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTMED6 also known as Transmembrane Emp24 domain-containing protein 6 plays a role in cellular transport processes. It is a protein with a mass of about 29 kDa. TMED6 is involved in the trafficking of proteins between the endoplasmic reticulum and the Golgi apparatus. Expression of TMED6 is seen in various tissues including liver heart and brain highlighting its broad relevance in different physiological processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTMED6 participates in maintaining the integrity of the secretory pathway. It is part of the p24 family which contributes to the coat protein complex (COPI and COPII) vesicles responsible for shuttling proteins between cellular compartments. This role facilitates the correct sorting and modification of proteins ensuring they reach their intended cellular destinations.\u003cbr\u003e\nPathways\u003cbr\u003e\nTMED6 has an integral part in the secretory pathway and the vesicular transport process. It interacts with proteins like COPI and COPII which are important for vesicle budding from the endoplasmic reticulum. The secretory pathway is essential for protein processing and trafficking affecting how cells respond to various stimuli and maintain homeostasis.\u003cbr\u003e\nResearchers have investigated TMED6's connection to conditions such as Alzheimer's disease and cardiovascular issues. Alzheimer's disease shows altered endoplasmic reticulum and Golgi function where TMED6's interactions with proteins such as gamma-secretase suggest a potential role in pathogenesis. Additionally cardiovascular disorders involve disruptions in protein transport pathways wherein TMED6's function in vesicular traffic could influence disease states.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843919237289,"sku":"ab165536","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab165536","provider":"Iright","version":"1.0","type":"link"}